Successful management of stage IV epithelioid trophoblastic tumor using multimodality treatment: A case report
| العنوان: | Successful management of stage IV epithelioid trophoblastic tumor using multimodality treatment: A case report |
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| المؤلفون: | Brannan B. Griffin, Brad J. Nakamura, Matthew Cowan, Jean Victoria Fischer, John R. Lurain, Anna E. Strohl |
| المصدر: | Gynecologic Oncology Reports, Vol 37, Iss, Pp 100802-(2021) Gynecologic Oncology Reports |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Epithelioid trophoblastic tumor, medicine.medical_treatment, 03 medical and health sciences, 0302 clinical medicine, Case Reports and Case Series, medicine, Chemotherapy, Epithelioid Trophoblastic Tumor, Etoposide, RC254-282, Gestational trophoblastic neoplasia, Cisplatin, 030219 obstetrics & reproductive medicine, business.industry, Choriocarcinoma, Obstetrics and Gynecology, Induction chemotherapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Gynecology and obstetrics, medicine.disease, Radiation therapy, Oncology, 030220 oncology & carcinogenesis, RG1-991, Methotrexate, Radiology, business, medicine.drug |
| الوصف: | Highlights • ETT is a rare variant of GTN that is more chemoresistant than choriocarcinoma. • Approximately 25–35% of patients with ETT present with metastatic disease. • Chemotherapy for ETT should consist of an etoposide/platinum-based regimen. • Multimodality treatment can result in successful management of stage IV ETT. Epithelioid trophoblastic tumor (ETT) is a rare variant of gestational trophoblastic neoplasia (GTN) that develops from chorionic-type intermediate trophoblast, is more resistant to chemotherapy than choriocarcinoma, and presents with metastatic disease in 25–35% of cases. We report a case of a 32-year-old who presented one week postpartum with severe abdominal pain and was found to have profound anemia and an elevated hCG level. CT scans and MRI revealed bleeding from hepatic masses, multiple hemorrhagic pulmonary nodules, a 7 cm uterine mass, and brain metastases. She underwent emergent hepatic embolization, was started on induction chemotherapy with weekly low-dose etoposide and cisplatin followed by a transition to etoposide, high-dose methotrexate, actinomycin D, etoposide, and cisplatin (HD EMA-EP), received stereotactic brain radiotherapy, and subsequently underwent minimally-invasive hysterectomy. She remains disease free over one year after the completion of treatment. An aggressive multimodal treatment approach employing etoposide/cisplatin-based chemotherapy as well as surgical procedures to control hemorrhage or excise resistant disease, and radiotherapy for brain metastases can result in successful treatment of stage IV ETT. |
| اللغة: | English |
| تدمد: | 2352-5789 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::447b2ef3b061eb95c64e8e56de690138 http://www.sciencedirect.com/science/article/pii/S2352578921001065 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....447b2ef3b061eb95c64e8e56de690138 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23525789 |
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