Effects of the 10-valent pneumococcal nontypeable Haemophilus influenzae protein D-conjugate vaccine on nasopharyngeal bacterial colonization in young children: a randomized controlled trial
| العنوان: | Effects of the 10-valent pneumococcal nontypeable Haemophilus influenzae protein D-conjugate vaccine on nasopharyngeal bacterial colonization in young children: a randomized controlled trial |
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| المؤلفون: | Ed P. F. IJzerman, Lode Schuerman, Menno R. van den Bergh, Arie van der Ende, Dorota Borys, Nancy François, Thierry G. Pascal, Jacob P. Bruin, Kristien Swinnen, Elisabeth A. M. Sanders, Reinier H. Veenhoven, Judith Spijkerman |
| المساهمون: | AII - Amsterdam institute for Infection and Immunity, Medical Microbiology and Infection Prevention |
| المصدر: | Clinical infectious diseases, 56(3), e30-e39. Oxford University Press Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, Microbiology (medical), Streptococcus pneumonia, Haemophilus Infections, Population, medicine.disease_cause, complex mixtures, Pneumococcal Infections, Pneumococcal conjugate vaccine, Haemophilus influenzae, Microbiology, Pneumococcal Vaccines, pneumococcal conjugate vaccination, Conjugate vaccine, Nasopharynx, Electronic Article, Streptococcus pneumoniae, medicine, otorhinolaryngologic diseases, Humans, nontypeable Haemophilus influenza, education, Immunization Schedule, carriage, education.field_of_study, business.industry, Diphtheria, Age Factors, Infant, medicine.disease, Bacterial Typing Techniques, Pneumococcal infections, Infectious Diseases, Child, Preschool, Host-Pathogen Interactions, nasopharyngeal bacterial colonization, Immunology, Female, business, Meningitis, medicine.drug |
| الوصف: | This study evaluated effects of the 10-valent pneumococcal nontypeable Haemophilus influenzae protein D-conjugate vaccine (PHiDCV) compared with the 7-valent vaccine on nasopharyngeal bacterial colonization, specifically nontypeable Haemophilus influenzae (NTHi). PHiD-CV had no differential effect on nasopharyngeal NTHi colonization. Background. This study evaluated the effects of the 10-valent pneumococcal nontypeable Haemophilus influenzae protein D–conjugate vaccine (PHiD-CV) on nasopharyngeal bacterial colonization compared with the 7-valent pneumococcal conjugate vaccine (7vCRM) in young children. Methods. A randomized controlled trial in the Netherlands, initiated 2 years after 7vCRM introduction, was conducted between 1 April 2008 and 1 December 2010. Infants (N = 780) received either PHiD-CV or 7vCRM (2:1) at 2, 3, 4, and 11–13 months of age. Nasopharyngeal samples taken at 5, 11, 14, 18, and 24 months of age were cultured to detect Haemophilus influenzae, Streptococcus pneumoniae, Moraxella catarrhalis, and Staphylococcus aureus. Polymerase chain reaction assays quantified H. influenzae and S. pneumoniae and confirmed H. influenzae as nontypeable (NTHi). Primary outcome measure was vaccine efficacy (VE) against NTHi colonization. Results. In both groups, NTHi colonization increased with age from 33% in 5-month-olds to 65% in 24-month-olds. Three months postbooster, VE against colonization was 0.5% (95% confidence interval [CI], −21.8% to 18.4%) and VE against acquisition 10.9% (95% CI, −31.3% to 38.9%). At each sampling moment, no differences between groups in either NTHi prevalence or H. influenzae density were detected. Streptococcus pneumoniae (range, 39%–57%), M. catarrhalis (range, 63%–69%), and S. aureus (range, 9%–30%) colonization patterns were similar between groups. Conclusions. PHiD-CV had no differential effect on nasopharyngeal NTHi colonization or H. influenzae density in healthy Dutch children up to 2 years of age, implying that herd effects for NTHi are not to be expected. Other bacterial colonization patterns were also similar. Clinical Trials Registration NCT00652951. |
| اللغة: | English |
| تدمد: | 1058-4838 |
| DOI: | 10.1093/cid/cis922 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::443da9cb6b3528217970445ba9a9941b https://doi.org/10.1093/cid/cis922 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....443da9cb6b3528217970445ba9a9941b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10584838 |
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| DOI: | 10.1093/cid/cis922 |