التفاصيل البيبلوغرافية
| العنوان: |
Current Practice in Untargeted Human Milk Metabolomics |
| المؤلفون: |
Guillermo Quintás, José David Piñeiro-Ramos, Victoria Ramos-Garcia, Isabel Ten-Doménech, Máximo Vento, Julia Kuligowski, María Gormaz, Anna Parra-Llorca |
| المصدر: |
Metabolites
Metabolites, Vol 10, Iss 2, p 43 (2020) |
| بيانات النشر: |
Zenodo, 2020. |
| سنة النشر: |
2020 |
| مصطلحات موضوعية: |
0301 basic medicine, Endocrinology, Diabetes and Metabolism, lcsh:QR1-502, Extraction, Review, Computational biology, Biology, 01 natural sciences, Biochemistry, lcsh:Microbiology, gas chromatography–mass spectrometry (GC-MS), 03 medical and health sciences, Metabolomics, Metabolome, Capillary electrophoresis – mass spectrometry (CE‐MS), Sampling, Molecular Biology, Liquid chromatography–mass spectrometry (LC‐MS), 030109 nutrition & dietetics, liquid chromatography–mass spectrometry (LC-MS), Gas chromatography–mass spectrometry (GC‐MS), 010401 analytical chemistry, human milk, Infant nutrition, CELL DEBRIS, capillary electrophoresis—mass spectrometry (CE-MS), 0104 chemical sciences, Current practice, Nuclear magnetic resonance (NMR) |
| الوصف: |
Human milk (HM) is considered the gold standard for infant nutrition. HM contains macro- and micronutrients, as well as a range of bioactive compounds (hormones, growth factors, cell debris, etc.). The analysis of the complex and dynamic composition of HM has been a permanent challenge for researchers. The use of novel, cutting-edge techniques involving different metabolomics platforms has permitted to expand knowledge on the variable composition of HM. This review aims to present the state-of-the-art in untargeted metabolomic studies of HM, with emphasis on sampling, extraction and analysis steps. Workflows available from the literature have been critically revised and compared, including a comprehensive assessment of the achievable metabolome coverage. Based on the scientific evidence available, recommendations for future untargeted HM metabolomics studies are included. |
| اللغة: |
English |
| DOI: |
10.5281/zenodo.4084692 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f500a5121dcc4a3f742109425571b7 |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....43f500a5121dcc4a3f742109425571b7 |
| قاعدة البيانات: |
OpenAIRE |