Antimicrobial susceptibility profiles of human and piglet Clostridium difficile PCR-ribotype 078
| العنوان: | Antimicrobial susceptibility profiles of human and piglet Clostridium difficile PCR-ribotype 078 |
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| المؤلفون: | Patrizia Spigaglia, Ed J. Kuijper, Len J.A. Lipman, M.P.M. Hensgens, E. C. Keessen, Fabrizio Barbanti, Ingrid M J G Sanders |
| المصدر: | Antimicrobial Resistance and Infection Control Antimicrobial Resistance and Infection Control, 2. BIOMED CENTRAL LTD |
| بيانات النشر: | Springer Science and Business Media LLC, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Microbiology (medical), Imipenem, Research, Public Health, Environmental and Occupational Health, Erythromycin, Clindamycin, Drug resistance, biochemical phenomena, metabolism, and nutrition, Biology, Clostridium difficile, Antimicrobial, Microbiology, Ciprofloxacin, Infectious Diseases, Moxifloxacin, medicine, Pharmacology (medical), medicine.drug |
| الوصف: | In the last decade, outbreaks of nosocomial Clostridium difficile infections (CDI) occurred worldwide. A new emerging type, PCR-ribotype 027, was the associated pathogen. Antimicrobial susceptibility profiles of this type were extensively investigated and used to partly explain its spread. In Europe, the incidence of C. difficile PCR-ribotype 078 recently increased in humans and piglets. Using recommendations of the European Committee on Antimicrobial Susceptibility Testing (EUCAST) and the Clinical and Laboratory Standards Institute (CLSI) we studied the antimicrobial susceptibility to eight antimicrobials, mechanisms of resistance and the relation with previously prescribed antimicrobials in human (n=49) and porcine (n=50) type 078 isolates. Human and porcine type 078 isolates showed similar antimicrobial susceptibility patterns for the antimicrobials tested. In total, 37% of the isolates were resistant to four or more antimicrobial agents. The majority of the human and porcine isolates were susceptible to amoxicillin (100%), tetracycline (100%) and clindamycin (96%) and resistant to ciprofloxacin (96%). More variation was found for resistance patterns to erythromycin (76% in human and 59% in porcine isolates), imipenem (29% in human and 50% in porcine isolates) and moxifloxacin (16% for both human and porcine isolates). MIC values of cefuroxim were high (MICs >256 mg/L) in 96% of the isolates. Resistance to moxifloxacin and clindamycin was associated with a gyr(A) mutation and the presence of the erm(B) gene, respectively. A large proportion (96%) of the erythromycin resistant isolates did not carry the erm(B) gene. The use of ciprofloxacin (humans) and enrofloxacin (pigs) was significantly associated with isolation of moxifloxacin resistant isolates. Increased fluoroquinolone use could have contributed to the spread of C. difficile type 078. |
| تدمد: | 2047-2994 |
| DOI: | 10.1186/2047-2994-2-14 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::439e10d2d172f4ab0518aa6cca60694b https://doi.org/10.1186/2047-2994-2-14 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....439e10d2d172f4ab0518aa6cca60694b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20472994 |
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| DOI: | 10.1186/2047-2994-2-14 |