Synthesis, Characterization, Antioxidant Status, and Toxicity Study of Vanadium–Rutin Complex in Balb/c Mice
| العنوان: | Synthesis, Characterization, Antioxidant Status, and Toxicity Study of Vanadium–Rutin Complex in Balb/c Mice |
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| المؤلفون: | Sougato Mallick, Balaram Ghosh, Tania Chakraborty, Subhadip Manna, Souvik Roy, Sumana Majumdar, Nilanjan Ghosh, Amit Singh |
| المصدر: | Biological Trace Element Research. 166:183-200 |
| بيانات النشر: | Springer Science and Business Media LLC, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, Vanadium Compounds, Antioxidant, Rutin, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Clinical Biochemistry, Pharmacology, Kidney, Biochemistry, Antioxidants, Intestinal absorption, BALB/c, Inorganic Chemistry, Mice, chemistry.chemical_compound, medicine, Animals, Mice, Inbred BALB C, biology, Chemistry, Stomach, Biochemistry (medical), Kidney metabolism, Vanadium, General Medicine, biology.organism_classification, Acute toxicity, Liver, Gastric Mucosa, Toxicity, Alkaline phosphatase |
| الوصف: | A new trend was developed for the formation of a complex between vanadium and flavonoid derivatives in order to increase the intestinal absorption and to reduce the toxicity of vanadium compounds. The vanadium-rutin complex was characterized by several spectroscopic techniques like ultraviolet (UV)-visible, Fourier transform infrared (FTIR), NMR, mass spectrometry, and microscopic evaluation by scanning electron microscopy. The mononuclear complex was formed by the interaction between vanadium and rutin with 1:2 metal to ligand stoichiometry. Antioxidant activity of the complex was evaluated by 1,1-diphenyl-2 picrylhydrazyl, ferric-reducing power, and 2,2'-azin-obis 3-ethylbenzothiazoline-6-sulphonic acid methods. It was shown that radical scavenging activity and ferric-reducing potential of free rutin was lower as compared with vanadium-rutin complex. The study was also investigated for oral acute toxicity and 28 days repeated oral subacute toxicity study of vanadium-rutin complex in balb/c mice. The vanadium-rutin complex showed mortality at a dose of 120 mg/kg in the balb/c mice. In 28 days repeated oral toxicity study, vanadium-rutin complex was administered to both sex of balb/c mice at dose levels of 90, 45, and 20 ppm, respectively. In addition, subacute toxicity study of vanadium-rutin complex (at 90 ppm dose level) showed increase levels of white blood cell (WBC), total bilirubin, alanine aminotransferase (ALT), alkaline phosphatase (ALP), aspartate aminotransferase (AST), creatinine, and blood urea nitrogen and decrease level of total protein (TP) as compared with control group. Histopathological study of vanadium-rutin showed structural alteration in the liver, kidney, and stomach at 90 ppm dose level. No observed toxic level of vanadium-rutin complex at 20 ppm dose level could be good for further study. |
| تدمد: | 1559-0720 0163-4984 |
| DOI: | 10.1007/s12011-015-0270-2 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433d69a9ead0c9cf6521f52dc43c62f8 https://doi.org/10.1007/s12011-015-0270-2 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....433d69a9ead0c9cf6521f52dc43c62f8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15590720 01634984 |
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| DOI: | 10.1007/s12011-015-0270-2 |