Toll-Like Receptor 7 Ligands Inhibit Influenza A Infection in Chickens
| العنوان: | Toll-Like Receptor 7 Ligands Inhibit Influenza A Infection in Chickens |
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| المؤلفون: | Sue Lowther, Terry G. Wise, Adam J. Karpala, Peter G. Mohr, Cameron R. Stewart, Andrew G. D. Bean, John W. Lowenthal, Audrey Bagnaud-Baule |
| المصدر: | Journal of Interferon & Cytokine Research. 32:46-51 |
| بيانات النشر: | Mary Ann Liebert Inc, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Immunology, Chick Embryo, Biology, Ligands, Virus Replication, In ovo, Antiviral Agents, Virus, Cell Line, Dogs, Immune system, Virology, Animals, Receptor, Toll-like receptor, Innate immune system, Guanosine, virus diseases, Cell Biology, TLR7, Poly I-C, Toll-Like Receptor 7, Influenza A virus, Influenza in Birds, TLR3, Interferons, Chickens, Spleen |
| الوصف: | Avian influenza virus is endemic in many regions around the world and remains a pandemic threat, a scenario tied closely to outbreaks of the virus in poultry. The innate immune system, in particular the nucleic acid-sensing toll-like receptors (TLRs) -3, -7, -8, and -9, play a major role in coordinating antiviral immune responses. In this study we have investigated the use of TLR ligands as antivirals against influenza A in chickens. The TLR7 ligand poly-C inhibited low-path influenza A growth in the chicken macrophage cell line HD-11 more effectively than poly(I:C), which acts via TLR3. The TLR7 ligand 7-allyl-8-oxoguanosine (loxoribine) inhibited influenza A replication in vitro and in ovo in a dose-dependent manner. Treatment of primary chicken splenocytes with loxoribine resulted in the induction of interferons-α, -β, and -λ, and interferon-stimulated genes PKR and Mx. These results demonstrate that nucleic acid-sensing TLR ligands show considerable potential as antivirals in chickens and could be incorporated into antiviral strategies. |
| تدمد: | 1557-7465 1079-9907 |
| DOI: | 10.1089/jir.2011.0036 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42f3107c99046a464d1e204f1ed9ae4b https://doi.org/10.1089/jir.2011.0036 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....42f3107c99046a464d1e204f1ed9ae4b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15577465 10799907 |
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| DOI: | 10.1089/jir.2011.0036 |