Takayasu arteritis in childhood: misdiagnoses at disease onset and associated diseases
| العنوان: | Takayasu arteritis in childhood: misdiagnoses at disease onset and associated diseases |
|---|---|
| المؤلفون: | Clovis A. Silva, Sheila Knupp Feitosa de Oliveira, Teresa Cristina Martins Vicente Robazzi, Maria Teresa Terreri, Marcia Bandeira, Virgínia Paes Leme Ferriani, Gleice Clemente, Silvana B. Sacchetti, Blanca Elena Rios Gomes Bica, Andre R. O. Cavalcanti, Flavio Sztajnbok |
| المصدر: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Adolescent, Spondyloarthropathy, Immunology, Diagnosis, Differential, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, medicine, Humans, Immunology and Allergy, DIAGNÓSTICO TARDIO, Arteritis, Diagnostic Errors, Fever of unknown origin, Child, Retrospective Studies, 030203 arthritis & rheumatology, Erythema nodosum, Polyarteritis nodosa, business.industry, Episcleritis, medicine.disease, Takayasu Arteritis, Dermatology, Polyarteritis Nodosa, Rheumatic fever, Female, Vasculitis, business, Brazil |
| الوصف: | Juvenile-Takayasu arteritis (j-TA) is a difficult diagnosis and some patients develop uncommon manifestations and associated diseases that may contribute to the delayed diagnosis. Our aim was to identify the misdiagnoses, the associated diseases and the atypical manifestations observed in a j-TA Brazilian multicentre study. 71 children and adolescents who met the classification criteria for j-TA were included. The misdiagnoses, the associated diseases and the atypical manifestations were evaluated. 19 (26.8%) patients had misdiagnoses. The most common of them was aortic coarctation in six (8.4%) patients, followed by rheumatic fever in five (7.0%) and one patient presented with both former diagnoses. Limb pain (two patients), spondyloarthropathy, juvenile idiopathic arthritis (JIA), spinal arteriovenous malformation, polyarteritis nodosa (PAN) and fever of unknown origin (FUO) were other misdiagnoses. Patients who had misdiagnoses previously to j-TA diagnosis presented a trend to have a longer diagnosis delay. 11 (15.5%) patients had 14 TA-associated diseases, such as pulmonary tuberculosis (5 patients), rheumatic fever (2 patients), spondyloarthropathy, polyarticular JIA, Crohn's disease, Prader-Willi disease, diabetes mellitus, Moyamoya and primary immunodeficiency. 7 (9.9%) patients presented 10 atypical manifestations, such as pyoderma gangrenosum, erythema nodosum, myositis, chorea, enthesitis, episcleritis, uveitis, hepatomegaly, splenomegaly and necrosis of extremities. Our study emphasizes the main misdiagnoses, associated diseases and atypical manifestations that occur in patients with j-TA and warns of the features that may alert paediatricians to this diagnosis, such as constitutional symptoms and elevated inflammatory markers. |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42786c4fc98c9c3ded4a272206011d8c |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....42786c4fc98c9c3ded4a272206011d8c |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |