The impact of transvenous cardioverter-defibrillator implantation on quality of life, depression and optimism in dialysis patients: report on the secondary outcome of QOL in the randomized controlled ICD2 trial
العنوان: | The impact of transvenous cardioverter-defibrillator implantation on quality of life, depression and optimism in dialysis patients: report on the secondary outcome of QOL in the randomized controlled ICD2 trial |
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المؤلفون: | Mihály K. de Bie, Martin J. Schalij, Rohit J. Timal, Hein Putter, J. Wouter Jukema, Maurits S Buiten, Joris I. Rotmans, Véronique De Gucht, Liselotte C.R. Hensen, Ton J. Rabelink |
المصدر: | Quality of Life Research, 30(6), 1605-1617. Springer Science and Business Media LLC Quality of Life Research Quality of Life Research, 30(6), 1605-1617. SPRINGER |
بيانات النشر: | Springer Science and Business Media LLC, 2021. |
سنة النشر: | 2021 |
مصطلحات موضوعية: | Male, medicine.medical_specialty, Randomization, medicine.medical_treatment, Population, 030232 urology & nephrology, 030204 cardiovascular system & hematology, Ventricular Function, Left, Article, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Renal Dialysis, Surveys and Questionnaires, Internal medicine, medicine, Humans, education, Depression (differential diagnoses), Dialysis, Aged, Aged, 80 and over, QOL, Optimism, education.field_of_study, Ejection fraction, Questionnaire, Depression, business.industry, ICD, Public Health, Environmental and Occupational Health, Stroke Volume, Middle Aged, Defibrillators, Implantable, Affect, Mood, Quality of Life, Female, Hemodialysis, business, Self-report, Personality |
الوصف: | Rationale The impact of prophylactic implantable cardioverter-defibrillator (ICD) implantation on the psychological well-being of patients on dialysis is unknown. Objective We aimed to identify the effect of primary ICD implantation on quality of life (QoL), mood and dispositional optimism in patients undergoing dialysis. Methods and results We performed a prespecified subanalysis of the randomized controlled ICD2 trial. In total, 177 patients on chronic dialysis, with an age of 55–81 years, and a left ventricular ejection fraction of ≥ 35%, were included in the per-protocol analysis. Eighty patients received an ICD for primary prevention, and 91 patients received standard care. The Short Form-36 (SF-36), Geriatric Depression Scale-15 (GDS-15), Revised Life Orientation Test (LOT-R) questionnaires were administered prior to ICD implantation (T0), and at 1-year follow-up (T1) to assess QoL, depression and optimism, respectively. The patients were predominantly male (76.0%), with a median age of 67 years. Hemodialysis was the predominant mode of dialysis (70.2%). The GDS-15 score difference (T1 − T0) was 0.5 (2.1) in the ICD group compared with 0.3 (2.2) in the control group (mean difference − 0.3; 95% CI − 1.1 to 0.6; P = 0.58). The LOT-R score difference was − 0.2 (4.1) in the ICD group compared with − 1.5 (4.0) in the control group (mean difference − 1.1 (0.8); 95% CI − 2.6 to 0.4; P = 0.17). The mean difference scores of all subscales of the SF-36 were not significantly different between randomization groups. Conclusions In our population of patients on dialysis, ICD implantation did not affect QoL, mood or dispositional optimism significantly during 1-year follow-up. Clinical Trial Registration Unique identifier: ISRCTN20479861. http://www.controlled-trials.com. |
وصف الملف: | application/pdf |
تدمد: | 1573-2649 0962-9343 |
DOI: | 10.1007/s11136-020-02744-7 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422fc9c8d5e16e7b33640b00356d002b https://doi.org/10.1007/s11136-020-02744-7 |
Rights: | OPEN |
رقم الانضمام: | edsair.doi.dedup.....422fc9c8d5e16e7b33640b00356d002b |
قاعدة البيانات: | OpenAIRE |
تدمد: | 15732649 09629343 |
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DOI: | 10.1007/s11136-020-02744-7 |