Selenium pretreatment attenuates formaldehyde-induced genotoxicity in A549 cell lines
| العنوان: | Selenium pretreatment attenuates formaldehyde-induced genotoxicity in A549 cell lines |
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| المؤلفون: | Yuqin Shi, Xin Chen, Zhong-Fa Jiang, Juan Dai, Ning Li, Zhi-Bing Zhang, Ben-Yan Zhang |
| المصدر: | Toxicology and Industrial Health. 30:901-909 |
| بيانات النشر: | SAGE Publications, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Antioxidant, Health, Toxicology and Mutagenesis, medicine.medical_treatment, Toxicology, medicine.disease_cause, Superoxide dismutase, Lipid peroxidation, Selenium, chemistry.chemical_compound, Cell Line, Tumor, Formaldehyde, Malondialdehyde, medicine, Humans, chemistry.chemical_classification, Reactive oxygen species, biology, Mutagenicity Tests, Superoxide Dismutase, Glutathione peroxidase, NF-kappa B, Public Health, Environmental and Occupational Health, Transcription Factor AP-1, Oxidative Stress, chemistry, Biochemistry, biology.protein, Oxidative stress, Genotoxicity, DNA Damage |
| الوصف: | Formaldehyde is a major industrial chemical and has been extensively used in the manufacture of synthetic resins and chemicals. Numerous studies indicate that formaldehyde can induce various genotoxic effects in vitro and in vivo. A recent study indicated that formaldehyde impaired antioxidant cellular defences and enhanced lipid peroxidation. Selenium is an important antioxidant. We hypothesized that reactive oxygen species (ROS) and lipid peroxidation are involved in formaldehyde-induced genotoxicity in human lung cancer cell line, A549 cell line. To test the hypothesis, we investigated the effects of selenium on formaldehyde-induced genotoxicity in A549 cell lines. The results indicated that exposure to formaldehyde showed the induction of DNA–protein cross-links (DPCs). Formaldehyde significantly increased the malondialdehyde levels and decreased the activities of superoxide dismutase and glutathione peroxidase. In addition, the activations of necrosis factor-κB (NF-κB) and activator protein 1 (AP-1) were induced by the formaldehyde treatment. The pretreatment with selenium counteracted the formaldehyde-induced oxidative stress, ameliorated DPCs and attenuated the activation of NF-κB and AP-1 in A549 cell lines. All the results suggested that the pretreatment with selenium attenuated the formaldehyde-induced genotoxicity through its ROS scavenging and anti-DPCs effects in A549 cell lines. |
| تدمد: | 1477-0393 0748-2337 |
| DOI: | 10.1177/0748233712466129 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4201d945df3ce83c7d0be5633fc23ae0 https://doi.org/10.1177/0748233712466129 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....4201d945df3ce83c7d0be5633fc23ae0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14770393 07482337 |
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| DOI: | 10.1177/0748233712466129 |