Reduced Left Atrial Emptying Fraction and Chymase Activation in Pathophysiology of Primary Mitral Regurgitation
| العنوان: | Reduced Left Atrial Emptying Fraction and Chymase Activation in Pathophysiology of Primary Mitral Regurgitation |
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| المؤلفون: | Inmaculada Aban, Thomas S. Denney, Navkaranbir S. Bajaj, Mustafa I. Ahmed, Michael J. Watson, Carlos M. Ferrario, Xiaoxia Zhang, James E. Davies, Himanshu Gupta, James W. McNamara, Betty Pat, Clifton T. Lewis, Louis J. Dell’Italia, James F. Collawn, Silvio H. Litovsky, Sakthivel Sadayappan, Brittany Butts, Steven G. Lloyd, Pamela C. Powell |
| المصدر: | JACC: Basic to Translational Science JACC: Basic to Translational Science, Vol 5, Iss 2, Pp 109-122 (2020) |
| بيانات النشر: | Elsevier, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, mitral valve, medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, left ventricle, CLINICAL RESEARCH, 030204 cardiovascular system & hematology, MV, mitral valve, MR, mitral regurgitation, left atrium, 03 medical and health sciences, 0302 clinical medicine, Fibrosis, Mitral valve, Internal medicine, Medicine, Myocyte, EF, ejection fraction, LA, left atrial, cardiovascular diseases, TEM, transmission electron microscopy, TGF, transforming growth factor, chymase, LA EF, left atrial emptying fraction, Mitral regurgitation, Ejection fraction, business.industry, fibrosis, Chymase, medicine.disease, Pathophysiology, RA, right atrial, 030104 developmental biology, medicine.anatomical_structure, LV, left ventricle, lcsh:RC666-701, Cardiology, cardiovascular system, mitral regurgitation, Cardiology and Cardiovascular Medicine, business, Myofibril |
| الوصف: | Visual Abstract Highlights • Extensive LA fibrosis is related to an increase in LA size and decrease in total LA EF. This supports the contention that the LA is not merely a bystander of MR but rather is actively involved in the pathophysiology of MR. • Chymase is plentiful in the human heart, especially in the LA, and correlates with extracellular matrix accumulation in primary MR. • Because of the unreliability of the LV ejection fraction in primary MR, future studies may consider LA size and total LA EF for timing of surgical intervention of asymptomatic moderate to severe MR. Summary Increasing left atrial (LA) size predicts outcomes in patients with isolated mitral regurgitation (MR). Chymase is plentiful in the human heart and affects extracellular matrix remodeling. Chymase activation correlates to LA fibrosis, LA enlargement, and a decreased total LA emptying fraction in addition to having a potential intracellular role in mediating myofibrillar breakdown in LA myocytes. Because of the unreliability of the left ventricular ejection fraction in predicting outcomes in MR, LA size and the total LA emptying fraction may be more suitable indicators for timing of surgical intervention. |
| اللغة: | English |
| تدمد: | 2452-302X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418707eb573e2e315a430793399ff571 http://europepmc.org/articles/PMC7046515 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....418707eb573e2e315a430793399ff571 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2452302X |
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