Prion protein is associated with a worse prognosis of head and neck squamous cell carcinoma
| العنوان: | Prion protein is associated with a worse prognosis of head and neck squamous cell carcinoma |
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| المؤلفون: | Carlos Alberto de Carvalho Fraga, André Luiz Sena Guimarães, Lucyana Conceição Farias, Alfredo Maurício Batista de Paula, Sérgio Henrique Sousa Santos, Marcela Gonçalves de Souza, Flavio H. Beraldo, Sabrina Ferreira de Jesus, Eloá Mangabeira Santos, Tiago G. Santos, Mauro Aparecido de Souza Xavier, Alessandra Rejane Ericsson de Oliveira Xavier |
| المصدر: | Journal of Oral Pathology & Medicine. 50:985-994 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cancer Research, animal diseases, Cell, Prion Proteins, Pathology and Forensic Medicine, PRNP, HSPA4, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Heat shock protein, Biomarkers, Tumor, medicine, Humans, Squamous Cell Carcinoma of Head and Neck, business.industry, 030206 dentistry, Prognosis, medicine.disease, Head and neck squamous-cell carcinoma, nervous system diseases, HIF1A, medicine.anatomical_structure, Otorhinolaryngology, Head and Neck Neoplasms, Cell culture, Case-Control Studies, 030220 oncology & carcinogenesis, Cancer research, Periodontics, Oral Surgery, business |
| الوصف: | Background Head and neck squamous cell carcinoma (HNSC) etiopathogenesis remains unclear, and the biological changes with the activation of heat shock proteins (HSPs) and prion protein (PRNP) promoted by hypoxia in HNSC are undetermined. Objective This study investigates hypoxia's effect in lymph node metastasis by PRNP expression changes and its main partners. Methods The study combined a theoretical/cell culture study with a case-control study. First, bioinformatics and cell culture were performed. A case-control study was performed in a second step by comparing HNSC patients with and without lymph node metastasis. Analyses The Cancer Genome Atlas (TCGA) data source validate the theory in the global population study. Results Bioinformatics analysis suggests that hypoxia-inducible factor-1α (HIF1A) is associated with HSPA4, HSP90AA1, and PRNP expression. TCGA data validate the hypothesis that higher HSP90AA1, HSPA4, and PRNP are related to metastases and low survival. Herein, the cell study demonstrated that muted PRNP did not respond to hypoxia. Conclusions Our results collectively provide the first evidence that PRNP promotes HNSC lymph node metastasis progression through the upregulation of HSPA4, HSP90AA1, and HIF1A. Our findings may provide a molecular basis for the promoting Role of PRNP in HNSC progression. |
| تدمد: | 1600-0714 0904-2512 |
| DOI: | 10.1111/jop.13188 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41293431f3bc859028ac1daa134464a4 https://doi.org/10.1111/jop.13188 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....41293431f3bc859028ac1daa134464a4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16000714 09042512 |
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| DOI: | 10.1111/jop.13188 |