التفاصيل البيبلوغرافية
| العنوان: |
Ethanol perturbs lipid organization in models of stratum corneum membranes: An investigation combining differential scanning calorimetry, infrared and 2H NMR spectroscopy |
| المؤلفون: |
Jenifer Thewalt, Denis B. Langlais, Sungjong Kwak, Elana Brief, Neil Kitson, Michel Lafleur |
| المصدر: |
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1818(5):1410-1419 |
| بيانات النشر: |
Elsevier BV, 2012. |
| سنة النشر: |
2012 |
| مصطلحات موضوعية: |
Deuterium NMR, Ceramide, Magnetic Resonance Spectroscopy, Spectrophotometry, Infrared, Biophysics, 02 engineering and technology, Stratum corneum, 010402 general chemistry, 01 natural sciences, Biochemistry, Epithelium, DSC, Palmitic acid, chemistry.chemical_compound, Differential scanning calorimetry, medicine, Animals, Humans, 2H NMR, Skin, Chromatography, Ethanol, Calorimetry, Differential Scanning, Membranes, Artificial, Nuclear magnetic resonance spectroscopy, Cell Biology, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Membrane, medicine.anatomical_structure, chemistry, Anti-Infective Agents, Local, Solvents, IR, lipids (amino acids, peptides, and proteins), 0210 nano-technology |
| الوصف: |
Ethanol is used in a variety of topical products. It is known to enhance the permeability of the skin by altering the ability of the stratum corneum (SC) intercellular membranes to form an effective barrier. In addition, ethanol and other alcohols are key components of antiseptic gels currently used for hand wash. Using infrared and deuterium NMR spectroscopy as well as calorimetry, we have investigated the effect of ethanol on a model membrane composed of lipids representing the three classes of SC lipids, an equimolar mixture of N-palmitoylsphingosine (ceramide), palmitic acid and cholesterol. Ethanol is found to influence the membrane in a dose dependent manner, disrupting packing and increasing lipid motion at low concentrations and selectively extracting lipids at moderate concentrations. |
| تدمد: |
0005-2736 |
| DOI: |
10.1016/j.bbamem.2012.02.013 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40dbc201285c49bd15b4f920b7d8868f |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....40dbc201285c49bd15b4f920b7d8868f |
| قاعدة البيانات: |
OpenAIRE |