Paroxysmal atrial fibrillation with high vs. low arrhythmia burden: atrial remodelling and ablation outcome
| العنوان: | Paroxysmal atrial fibrillation with high vs. low arrhythmia burden: atrial remodelling and ablation outcome |
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| المؤلفون: | Rene Tavernier, Y Vandekerckhove, Thomas Phlips, M El Haddad, Teresa Strisciuglio, Alexandre Almorad, Mattias Duytschaever, Maria Kyriakopoulou, Michael Wolf, Philippe Debonnaire, Anthony Demolder, S Knecht, J De Pooter |
| المساهمون: | Strisciuglio, T, El Haddad, M, Debonnaire, P, De Pooter, J, Demolder, Anthony, Wolf, M, Phlips, T, Kyriakopoulou, M, Almorad, A, Knecht, S, Tavernier, R, Vandekerckhove, Y, Duytschaever, Mattias |
| المصدر: | EP Europace. 22:1189-1196 |
| بيانات النشر: | Oxford University Press (OUP), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Refractory period, medicine.medical_treatment, Catheter ablation, Nerve conduction velocity, Physiology (medical), Internal medicine, Atrial Fibrillation, medicine, Humans, Heart Atria, Atrial tachycardia, Atrium (architecture), business.industry, Cardiac arrhythmia, Atrial fibrillation, Atrial Remodeling, Cardiac Ablation, medicine.disease, Treatment Outcome, Pulmonary Veins, Catheter Ablation, Cardiology, medicine.symptom, Cardiology and Cardiovascular Medicine, business |
| الوصف: | Aims The relation between atrial tachyarrhythmia (ATA) burden in paroxysmal atrial fibrillation (AF), atrial remodelling, and efficacy of catheter ablation (CA) is unknown. We investigated whether high vs. low-burden paroxysmal AF patients have distinct clinical characteristics or electro-mechanical properties of the left atrium (LA) and whether burden impacts outcome of CA. Methods and results Atrial tachyarrhythmia burden, defined as the percentage of time spent in ATA, was assessed by insertable cardiac monitors in 105 patients before and after CA. Clinical characteristics and electro-mechanical properties of LA were compared between patients with high vs. low ATA burden. Catheter ablation efficacy was assessed by reduction in ATA burden and 1-year freedom from any ATA. Median ATA burden was 2.7% (highest tertile 9.3%). Clinical characteristics and electrical properties of LA (refractoriness, conduction velocity, low voltage) did not differ between high (≥9.3%) vs. low ATA burden ( Conclusion Paroxysmal AF patients with high ATA burden have altered LA mechanical properties, reflected by larger size and impaired function. Despite mechanical remodelling of the atria, they are excellent responders to CA. Most likely the lack of fibrosis and/or advanced electrical remodelling explain why pulmonary veins remain the dominant trigger for AF in this patient cohort. |
| تدمد: | 1532-2092 1099-5129 |
| DOI: | 10.1093/europace/euaa071 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::404fc1e50595ca2d8629168be2f046eb https://doi.org/10.1093/europace/euaa071 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....404fc1e50595ca2d8629168be2f046eb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15322092 10995129 |
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| DOI: | 10.1093/europace/euaa071 |