High-Dose Therapy and Autologous Bone Marrow Transplantation in First Complete or Partial Remission for Poor Prognosis Hodgkin's Disease
| العنوان: | High-Dose Therapy and Autologous Bone Marrow Transplantation in First Complete or Partial Remission for Poor Prognosis Hodgkin's Disease |
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| المؤلفون: | Didier Blaise, Dominique Maraninchi, Philippe Chollet, J. Fleury, J. P. Lamagnere, Philippe Travade, Patrice Viens, R. Plagne, Claude Linassier, Michel Legros, Claude Dionet, Philippe Colombat, Jacques Tortochaux, Hervé Curé |
| المصدر: | Leukemia & Lymphoma. 20:259-266 |
| بيانات النشر: | Informa UK Limited, 1996. |
| سنة النشر: | 1996 |
| مصطلحات موضوعية: | Adult, Male, Cancer Research, medicine.medical_specialty, Poor prognosis, Adolescent, Lymphocyte, medicine.medical_treatment, Antineoplastic Agents, Disease, Transplantation, Autologous, Disease-Free Survival, medicine, Humans, Stage (cooking), Bone Marrow Transplantation, business.industry, Hematology, Middle Aged, Autologous bone, Combined Modality Therapy, Hodgkin Disease, Survival Analysis, Surgery, Radiation therapy, medicine.anatomical_structure, Oncology, ABVD, Female, Bone marrow, business, medicine.drug |
| الوصف: | We report the experience of three French centres which evaluated high-dose therapy (HDT) as consolidation therapy for poor prognosis Hodgkin's disease (HD). From March 1986 to April 1990, 23 consecutive patients with poor prognosis stage IV HD underwent HDT followed by autologous bone marrow transplantation (ABMT) after achieving either complete remission (CR1) or good partial response (GPR1) (reduction mass75%). The median age was 31 years (range 18 to 55 years), 14 were male. All patients except one initially had at least 2 poor prognosis factors such as: systemic symptoms (n = 19), bulky tumor (n = 16), more than one extranodal site (n = 9), bone marrow involvement (n = 5), lymphocyte countor = 1.10(9)/1 (n = 8) and biological stage B (n = 21). All patients had previously been treated with alternating MOPP/ABVD. Ten patients were in GPR1 and 13 in CR1 before transplant. The conditioning regimens were: CBV (n = 17), BEAM (n = 5), BEAC (n = 1) followed by bone marrow rescue. Radiotherapy was introduced just before the conditioning regimen for 6 patients or after ABMT for 5 patients. Nine of 10 patients in GPR1 achieved CR after ABMT but one died early of treatment-related toxicity. Five of 22 patients who were in CR posttransplant, relapsed (3, 4, 4, 18, 36 months). Seventeen patients remain alive in continuous CR with a median follow-up of 60 months (range: 30-100 months). The overall survival (OS) and disease-free survival (DFS) projected at 5 years are 92% and 77% respectively. Consolidation by HDT and ABMT proved to be well tolerated. An international trial is currently underway to attempt to demonstrate a clear benefit on survival for this subset of poor prognosis HD patients. |
| تدمد: | 1029-2403 1042-8194 |
| DOI: | 10.3109/10428199609051616 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fec272d9c5dd6ff799720aaa4e7963a https://doi.org/10.3109/10428199609051616 |
| رقم الانضمام: | edsair.doi.dedup.....3fec272d9c5dd6ff799720aaa4e7963a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10292403 10428194 |
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| DOI: | 10.3109/10428199609051616 |