Effect of plasma rich in growth factors on the early phase of healing of surgically severed Achilles tendon in sheep: histological study
| العنوان: | Effect of plasma rich in growth factors on the early phase of healing of surgically severed Achilles tendon in sheep: histological study |
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| المؤلفون: | Juan M. Domínguez, José M. Carrillo, M.M. Granados, Rocío Navarrete, Juan Morgaz, José Andrés Fernández-Sarmiento, Daniel Aguilar-García, Jose M. Vilar, Ramón Cugat |
| المساهمون: | UCH. Departamento de Medicina y Cirugía Animal, Producción Científica UCH 2018 |
| المصدر: | Journal of Applied Animal Research, Vol 46, Iss 1, Pp 471-478 (2018) CEU Repositorio Institucional Fundación Universitaria San Pablo CEU (FUSPCEU) |
| بيانات النشر: | Taylor & Francis Group, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | musculoskeletal diseases, medicine.medical_specialty, Pathology, medicine.medical_treatment, Tendon reconstruction, 03 medical and health sciences, Achilles tendon - Wounds and injuries - Treatment, 0302 clinical medicine, medicine, Crecimiento - Factores - Uso terapéutico, Saline, Tendon healing, PRGF, 030222 orthopedics, Achilles tendon, Growth factors - Therapeutic use, lcsh:Veterinary medicine, General Veterinary, business.industry, 030229 sport sciences, musculoskeletal system, Surgery, Musculoskeletal problems, Tendon, Achilles tendon - Regeneration, medicine.anatomical_structure, inflammation, regeneration, lcsh:SF600-1100, Animal Science and Zoology, Tendón de Aquiles - Heridas y lesiones - Tratamiento, Plasma sanguíneo - Uso terapéutico, Early phase, business, Blood plasma - Therapeutic use, Tendón de Aquiles - Regeneración |
| الوصف: | Este artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://www.tandfonline.com/doi/full/10.1080/09712119.2017.1337017 Tendon injuries are the most frequent musculoskeletal problems, constituting 30–50% of all sport-related lesions. Efficient handling of early stage tendon injury and healing can accelerate tendon repair as well as improve the quality of newly formed tendons. Plasma rich in growth factors (PRGF) is an autologous biological therapy that has been proposed to treat tendon injuries. To elucidate the effect of this treatment on the early stage of tendon healing, 14 sheep were used to perform the present study. The right Achilles tendon was surgically severed and repaired with sutures. Seven animals were treated with PRGF and the other seven with saline solution after surgical tendon reconstruction. Tendons were ultrasound-guide infiltrated 1 week after the induced injury. Two weeks later, the sheep were euthanized and histochemical and immunohistochemical analyses were performed. The tendons with PRGF showed reduced infiltration of inflammatory cells compared to those treated with saline solution. Analysis of the blood vessels, morphometric data of fibroblast nuclei, and collagen fibres in the extracellular matrix did not show statistical differences between groups. These findings suggest the important role that PRGF therapy plays in the modulation of inflammatory response in Achilles tendon injuries, leading to acceleration of the tendon healing process, shortening the convalescence period. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0974-1844 0971-2119 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc880d26f8675555bedcb978f40a1f8 https://doaj.org/article/acf578d3cd2f4b5d989b61af5f6cbf68 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3fc880d26f8675555bedcb978f40a1f8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09741844 09712119 |
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