التفاصيل البيبلوغرافية
| العنوان: |
The antimalarial drug quinine interferes with serotonin biosynthesis and action |
| المؤلفون: |
Sarah M. Tindall, Karen Swift, Simon V. Avery, Kevin C. F. Fone, Farida Hanim Islahudin, Kang Nee Ting, Richard J. Pleass, Ian R. Mellor, Hans Erik Mølager Christensen |
| المصدر: |
Islahudin, F, Tindall, S M, Mellor, I R, Swift, K, Christensen, H E M, Fone, K C F, Pleass, R J, Ting, K-N & Avery, S V 2014, ' The antimalarial drug quinine interferes with serotonin biosynthesis and action ', Scientific Reports, vol. 4, 3618 . https://doi.org/10.1038/srep03618
Scientific Reports |
| بيانات النشر: |
Nature Publishing Group, 2014. |
| سنة النشر: |
2014 |
| مصطلحات موضوعية: |
Kynurenine pathway, 60504, Parasitology - Medical, plasma blood and lymphatics, 10060, Biochemistry studies - General, Tryptophan Hydroxylase, Pharmacology, Fungi Plantae (Fungi, Microorganisms, Nonvascular Plants, Plants) - Ascomycetes [15100] Saccharomyces cerevisiae species, Neuroblastoma, chemistry.chemical_compound, FALCIPARUM-MALARIA, qv_257, qv_256, BRAIN, Neurotransmitter, 15002, Blood - Blood and lymph studies, Quinine, 22002, Pharmacology - General, 36008, Medical and clinical microbiology - Mycology, Multidisciplinary, TRYPTOPHAN-HYDROXYLASE, TPH2, PLASMA, 38510, Chemotherapy - Antiparasitic agents, PROLIFERATION, 38502, Chemotherapy - General, methods and metabolism, Hematology, 12512, Pathology - Therapy, 15006, Blood - Blood, lymphatic and reticuloendothelial pathologies, 60502, Parasitology - General, 15004, Blood - Blood cell studies, RECEPTORS, qv_126, Biochemistry, Serotonin Production, DEPLETION, drug development, enzyme mechanisms, malaria, mechanism of action, BEHAVIOR, medicine.drug, Serotonin, quinine 130-95-0 antiinfective-drug, antiparasitic-drug, Fungi Plantae (Fungi, Microorganisms, Nonvascular Plants, Plants) - Fungi Imperfecti or Deuteromycetes [15500] Candida albicans species, INHIBITION, neurotransmitter serotonin-5 5-HT receptor synthesis, Saccharomyces cerevisiae, Biology, Human Medicine, Medical Sciences, qv_38, 22005, Pharmacology - Clinical pharmacology, Article, Antimalarials, KYNURENINE PATHWAY, SDG 3 - Good Health and Well-being, Cell Line, Tumor, medicine, Humans, tryptophan 73-22-3, Primates Mammalia Vertebrata Chordata Animalia (Animals, Chordates, Humans, Mammals, Primates, Vertebrates) - Hominidae [86215] SHSY5Y cell line cell_line human neuroblastoma cells, 10064, Biochemistry studies - Proteins, peptides and amino acids, Tryptophan, Tryptophan hydroxylase, wc_750, chemistry, 02508, Cytology - Human, Parasitology, malaria Malaria (MeSH) blood and lymphatic disease, parasitic disease drug therapy, symptom, MULTIDISCIPLINARY, tryptophan hydroxylase TPH2 9037-21-2 EC 1.14.16.4 |
| الوصف: |
The major antimalarial drug quinine perturbs uptake of the essential amino acid tryptophan and patients with low plasma tryptophan are predisposed to adverse quinine reactions; symptoms of which are similar to indications of tryptophan depletion. As tryptophan is a precursor of the neurotransmitter serotonin (5-HT), here we test the hypothesis that quinine disrupts serotonin function. Quinine inhibited serotonin-induced proliferation of yeast as well as human (SHSY5Y) cells. One possible cause of this effect is through inhibition of 5-HT receptor activation by quinine, as we observed here. Furthermore, cells exhibited marked decreases in serotonin production during incubation with quinine. By assaying activity and kinetics of the rate-limiting enzyme for serotonin biosynthesis, tryptophan hydroxylase (TPH2), we showed that quinine competitively inhibits TPH2 in the presence of the substrate tryptophan. The study shows that quinine disrupts both serotonin biosynthesis and function, giving important new insight to the action of quinine on mammalian cells. |
| وصف الملف: |
application/pdf; PDF |
| اللغة: |
English |
| تدمد: |
2045-2322 |
| DOI: |
10.1038/srep03618 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f244bec9e289ab069114065745a74fd |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....3f244bec9e289ab069114065745a74fd |
| قاعدة البيانات: |
OpenAIRE |