Framework nucleic acids as programmable carrier for transdermal drug delivery
| العنوان: | Framework nucleic acids as programmable carrier for transdermal drug delivery |
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| المؤلفون: | Mengjia Zheng, Chenjie Xu, Lihua Wang, Chunhai Fan, Christian Wiraja, Weina Fang, David C. Yeo, Ying Zhu, Qian Li, Maurice A.M. van Steensel, Daniel Chin Shiuan Lio, Mo Xie |
| المصدر: | Nature Communications Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019) |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Biodistribution, Skin Neoplasms, Swine, Science, Melanoma, Experimental, General Physics and Astronomy, Mice, Nude, Human skin, 02 engineering and technology, Administration, Cutaneous, General Biochemistry, Genetics and Molecular Biology, Permeability, Article, 03 medical and health sciences, Mice, Drug Delivery Systems, Nucleic Acids, Animals, Humans, lcsh:Science, Transdermal, Skin, Liposome, Multidisciplinary, Antibiotics, Antineoplastic, Chemistry, General Chemistry, Penetration (firestop), 021001 nanoscience & nanotechnology, 030104 developmental biology, Doxorubicin, Delayed-Action Preparations, Drug delivery, Systemic administration, lcsh:Q, 0210 nano-technology, Drug carrier, Biomedical engineering |
| الوصف: | DNA nanostructures are promising drug carriers with their intrinsic biocompatibility, uniformity and versatility. However, rapid serum disintegration leads to low bioavailability at targeted sites following systemic administration, hindering their biomedical applications. Here we demonstrate transdermal delivery of framework nucleic acids (FNAs) through topical applications. By designing FNAs with distinct shapes and sizes, we interrogate their penetration on mice and human skin explant. Skin histology reveals size-dependent penetration, with FNAs ≤75 nm effectively reaching dermis layer. 17 nm-tetrahedral FNAs show greatest penetration to 350 µm from skin periphery. Importantly, structural integrity is maintained during the skin penetration. Employing a mouse melanoma model, topical application of doxorubicin-loaded FNAs accommodates ≥2-fold improvement in drug accumulation and tumor inhibition relative to topically-applied free doxorubicin, or doxorubicin loaded in liposomes and polymeric nanoparticles. Programmable penetration with minimal systemic biodistribution underlines FNA potential as localized transdermal drug delivery carriers. DNA nanostructures hold great promise for drug delivery, but systemic administration is problematic. Here, the authors demonstrate that framework nucleic acids (FNAs) improve drug accumulation in tumours in topical application and that penetration depth is controllable through adjusting FNA size. |
| تدمد: | 2041-1723 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e5ae950a0d2bdc843fb0c03c3ed1184 https://pubmed.ncbi.nlm.nih.gov/30850596 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3e5ae950a0d2bdc843fb0c03c3ed1184 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20411723 |
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