Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study
| العنوان: | Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study |
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| المؤلفون: | Pierre Leich, Nicolas Fakhry, Chiara Falanga, Jerome R. Lechien, Christel Souchay, Stéphane Hans, Cosimo de Filippis, Tareck Ayad, Carlos M. Chiesa-Estomba, Fabrice Journe, Philippe Lavigne, Camelia Rossi, Myriam Edjlali, Fahd El Afia, Robert Carlier, Sven Saussez, Frédérique Coppée, Mohamad Khalife, Christian Calvo-Henriquez, Andrea Lovato, Maria Rosaria Barillari, Laurence Ris, Alexandra Rodriguez, Giovanni Cammaroto, Daniele R De Siati, Serge Blecic, Didier Dequanter, Julien Hsieh, Younes Chekkoury-Idrissi, Mihaela Horoi, Irene Lopez Delgado, Lea Distinguin, Serge D Le Bon |
| المساهمون: | SFORL (SFORL), SFORL, Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Handicap neuromusculaire : Physiopathologie, Biothérapie et Pharmacologies appliquées (END-ICAP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Aix Marseille Université (AMU), Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Laboratoire Parole et Langage (LPL), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Lechien, J. R., Chiesa-Estomba, C. M., De Siati, D. R., Horoi, M., Le Bon, S. D., Rodriguez, A., Dequanter, D., Blecic, S., El Afia, F., Distinguin, L., Chekkoury-Idrissi, Y., Hans, S., Delgado, I. L., Calvo-Henriquez, C., Lavigne, P., Falanga, C., Barillari, M. R., Cammaroto, G., Khalife, M., Leich, P., Souchay, C., Rossi, C., Journe, F., Hsieh, J., Edjlali, M., Carlier, R., Ris, L., Lovato, A., De Filippis, C., Coppee, F., Fakhry, N., Ayad, T., Saussez, S. |
| المصدر: | European Archives of Oto-Rhino-Laryngology European Archives of Oto-Rhino-Laryngology, Springer Verlag, 2020, 277 (8), pp.2251-2261. ⟨10.1007/s00405-020-05965-1⟩ European Archives of Oto-Rhino-Laryngology, 2020, 277 (8), pp.2251-2261. ⟨10.1007/s00405-020-05965-1⟩ |
| بيانات النشر: | HAL CCSD, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Anosmia, [SDV]Life Sciences [q-bio], Coronaviru, ENT, Olfaction, Dysgeusia, 03 medical and health sciences, 0302 clinical medicine, Hyposmia, Internal medicine, medicine, 030223 otorhinolaryngology, COVID, business.industry, SARS-CoV-2, Hypogeusia, Coronavirus, COVID-19, Gustatory, Infection, Loss, Olfactory, Smell, Taste, Lo, General Medicine, Ageusia, Parosmia, 3. Good health, Taste disorder, Otorhinolaryngology, 030220 oncology & carcinogenesis, medicine.symptom, business |
| الوصف: | International audience; Objective: To investigate the occurrence of olfactory and gustatory dysfunctions in patients with laboratory-confirmed COVID-19 infection. Methods: Patients with laboratory-confirmed COVID-19 infection were recruited from 12 European hospitals. The following epidemiological and clinical outcomes have been studied: age, sex, ethnicity, comorbidities, and general and otolaryngological symptoms. Patients completed olfactory and gustatory questionnaires based on the smell and taste component of the National Health and Nutrition Examination Survey, and the short version of the Questionnaire of Olfactory Disorders-Negative Statements (sQOD-NS). Results: A total of 417 mild-to-moderate COVID-19 patients completed the study (263 females). The most prevalent general symptoms consisted of cough, myalgia, and loss of appetite. Face pain and nasal obstruction were the most disease-related otolaryngological symptoms. 85.6% and 88.0% of patients reported olfactory and gustatory dysfunctions, respectively. There was a significant association between both disorders (p < 0.001). Olfactory dysfunction (OD) appeared before the other symptoms in 11.8% of cases. The sQO-NS scores were significantly lower in patients with anosmia compared with normosmic or hyposmic individuals (p = 0.001). Among the 18.2% of patients without nasal obstruction or rhinorrhea, 79.7% were hyposmic or anosmic. The early olfactory recovery rate was 44.0%. Females were significantly more affected by olfactory and gustatory dysfunctions than males (p = 0.001). Conclusion: Olfactory and gustatory disorders are prevalent symptoms in European COVID-19 patients, who may not have nasal symptoms. The sudden anosmia or ageusia need to be recognized by the international scientific community as important symptoms of the COVID-19 infection. |
| اللغة: | English |
| تدمد: | 0937-4477 1434-4726 |
| DOI: | 10.1007/s00405-020-05965-1⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e4fb3401a883602928dab19869b1dce https://hal.archives-ouvertes.fr/hal-03222544 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3e4fb3401a883602928dab19869b1dce |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09374477 14344726 |
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| DOI: | 10.1007/s00405-020-05965-1⟩ |