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Resolution of a CPzI precursor, synthesis and biological evaluation of (+) and (-)-N-Boc-CPzI: a further validation of the relationship between chemical solvolytic stability and cytotoxicity

التفاصيل البيبلوغرافية
العنوان: Resolution of a CPzI precursor, synthesis and biological evaluation of (+) and (-)-N-Boc-CPzI: a further validation of the relationship between chemical solvolytic stability and cytotoxicity
المؤلفون: Giampiero Spalluto, Pier Giovanni Baraldi, Barbara Cacciari, Romeo Romagnoli, Dale L. Boger, Christopher W. Boyce
المساهمون: Baraldi, Pg, Cacciari, B, Romagnoli, R, Spalluto, Giampiero, Boyce, Cw, Boger, Dl
المصدر: Bioorganicmedicinal chemistry letters. 9(21)
سنة النشر: 1999
مصطلحات موضوعية: Indoles, Proline, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Stereoisomerism, Pyrazole, Biochemistry, Chemical synthesis, Leucomycins, Cyclopropane, chemistry.chemical_compound, Duocarmycins, Mice, Drug Discovery, Tumor Cells, Cultured, Molecule, Animals, Leukemia L1210, Molecular Biology, Antineoplastic Agents, Alkylating, Chiral auxiliary, Antibiotics, Antineoplastic, Molecular Structure, Chemistry, Organic Chemistry, Enantioselective synthesis, Streptomyces, Molecular Medicine, Pyrazoles, Enantiomer
الوصف: The chemical resolution, using N-tosyl-L-proline as a chiral auxiliary, of a racemate of the pyrazole analog (+/-)-N-Boc-CPzI of the left hand segment (CPI) of the antitumor agent CC-1065, and the cytotoxic evaluation of both enantiomers are described. The reported results further validate the direct relationship between chemical solvolytic stability of the cyclopropane ring and cytotoxicity proposed by Boger and coworkers.
تدمد: 0960-894X
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dd156e8cb3e4a3bf73061925673bb5a
https://pubmed.ncbi.nlm.nih.gov/10560730
Rights: OPEN
رقم الانضمام: edsair.doi.dedup.....3dd156e8cb3e4a3bf73061925673bb5a
قاعدة البيانات: OpenAIRE
الوصف
تدمد:0960894X