Collaborative Biosynthesis of Maleimide- and Succinimide-Containing Natural Products by Fungal Polyketide Megasynthases
| العنوان: | Collaborative Biosynthesis of Maleimide- and Succinimide-Containing Natural Products by Fungal Polyketide Megasynthases |
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| المؤلفون: | Jaclyn M. Winter, Leibniz Hang, Michio Sato, Shu-Shan Gao, Neil K. Garg, Yi Tang, Yiu-Sun Hung, Kenji Watanabe, Jacob E. Dander, Man-Cheng Tang, Chizuru Sato |
| المصدر: | Journal of the American Chemical Society. 139:5317-5320 |
| بيانات النشر: | American Chemical Society (ACS), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Stereochemistry, Molecular Conformation, Succinimides, Peptide, 010402 general chemistry, 01 natural sciences, Biochemistry, Article, Catalysis, Maleimides, chemistry.chemical_compound, Polyketide, Colloid and Surface Chemistry, Biosynthesis, Succinimide, polycyclic compounds, Maleimide, Adenylylation, chemistry.chemical_classification, Biological Products, 010405 organic chemistry, Penicillium, General Chemistry, 0104 chemical sciences, Amino acid, chemistry, Polyketide Synthases, Function (biology) |
| الوصف: | Fungal polyketide synthases (PKSs) can function collaboratively to synthesize natural products of significant structural diversity. Here we present a new mode of collaboration between a highly reducing PKS (HRPKS) and a PKS-nonribosomal peptide synthetase (PKS-NRPS) in the synthesis of oxaleimides from the Penicillium species. The HRPKS is recruited in the synthesis of an olefin-containing free amino acid, which is activated and incorporated by the adenylation domain of the PKS-NRPS. The precisely positioned olefin from the unnatural amino acid is proposed to facilitate a scaffold rearrangement of the PKS-NRPS product to forge the maleimide and succinimide cores of oxaleimides. |
| تدمد: | 1520-5126 0002-7863 |
| DOI: | 10.1021/jacs.7b02432 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3e25e288d5a9ba85008f1d17b1db7b https://doi.org/10.1021/jacs.7b02432 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3d3e25e288d5a9ba85008f1d17b1db7b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15205126 00027863 |
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| DOI: | 10.1021/jacs.7b02432 |