Diagnostic Value of Preoperative Haemoglobin, Albumin, Lymphocyte and Platelet (HALP) Score in Predicting Tumour Budding in Colorectal Cancer
| العنوان: | Diagnostic Value of Preoperative Haemoglobin, Albumin, Lymphocyte and Platelet (HALP) Score in Predicting Tumour Budding in Colorectal Cancer |
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| المؤلفون: | Ugur, Topal, Serkan, Guler, Zafer, Teke, Erdal, Karakose, Idris, Kurtulus, Hasan, Bektas |
| المصدر: | Journal of the College of Physicians and Surgeons Pakistan. 32:751-757 |
| بيانات النشر: | College of Physicians and Surgeons Pakistan, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Hemoglobins, Albumins, Humans, Lymphocytes, General Medicine, Colorectal Neoplasms, Prognosis, Retrospective Studies |
| الوصف: | To investigate the value of preoperative haemoglobin, albumin, lymphocyte, and platelet (HALP) score in predicting tumour budding in colorectal carcinoma.Observational study.University of Health Sciences, Başakşehir Çam and Sakura City Hospital İstanbul/Turkey, between May 2020 and May 2021.The colorectal cancer patients who underwent surgery were divided into two groups according to the presence or absence of tumour budding. A total of 110 patients were included in the study, and there were 31 patients in group 1 and 79 patients in group 2. The predictive value of the HALP score in predicting tumour budding at the determined cut-off point was evaluated.The mean HALP score was similar in both groups (p=0.459). The rate of lymphovascular invasion was higher in group 2 (p=0.002), and T3 and T4 tumours were more common in group 2 (p0.001). The number of metastatic lymph nodes was higher in group 2 (p=0.049). When the patients in group 2 were divided into subgroups according to the degree of tumour budding, the HALP score differed between intermediate and high budding groups (p=0.032). A HALP value of31.6 predicted the presence of tumour budding with a sensitivity of 70.89% and a specificity of 48.39%.The presence of tumour budding is associated with aggressive phenotypic features in colorectal carcinoma. The preoperative prediction of tumour budding can serve as a guide in the development of individualised therapy plans. The HALP score was associated with the presence of intermediate or high degree of tumour budding.Colorectal cancer, Tumor, Pathology, Hemoglobin, Albumin. |
| تدمد: | 1681-7168 1022-386X |
| DOI: | 10.29271/jcpsp.2022.06.751 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d2cfdc89930be3445292e4b193c6b5f https://doi.org/10.29271/jcpsp.2022.06.751 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3d2cfdc89930be3445292e4b193c6b5f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16817168 1022386X |
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| DOI: | 10.29271/jcpsp.2022.06.751 |