Use of adjunctive topical corticosteroids in bacterial keratitis

التفاصيل البيبلوغرافية
العنوان: Use of adjunctive topical corticosteroids in bacterial keratitis
المؤلفون: Stephen D. McLeod, Nina Ni, Muthiah Srinivasan, Nisha R. Acharya, Jennifer Rose-Nussbaumer, Thomas M. Lietman
المصدر: Current opinion in ophthalmology, vol 27, iss 4
سنة النشر: 2016
مصطلحات موضوعية: Administration, Topical, Antibiotics, Eye Infections, Visual Acuity, Ophthalmology & Optometry, Eye Infections, Bacterial, 0302 clinical medicine, Adrenal Cortex Hormones, Medicine, 030212 general & internal medicine, Randomized Controlled Trials as Topic, Bacterial, Bacterial keratitis, bacterial keratitis, General Medicine, Anti-Bacterial Agents, Infectious Diseases, Topical, 6.1 Pharmaceuticals, Combination, Administration, Steroids for Corneal Ulcers Trial, Corticosteroid use, Drug Therapy, Combination, Infection, hormones, hormone substitutes, and hormone antagonists, medicine.medical_specialty, corticosteroid, medicine.drug_class, Clinical Trials and Supportive Activities, Infectious Keratitis, Article, Keratitis, 03 medical and health sciences, Pharmacotherapy, Drug Therapy, Clinical Research, Opthalmology and Optometry, Humans, Corneal Ulcer, Eye Disease and Disorders of Vision, business.industry, Evaluation of treatments and therapeutic interventions, Eye infection, medicine.disease, corneal ulcer, Dermatology, Ophthalmology, 030221 ophthalmology & optometry, business
الوصف: Purpose of reviewTopical corticosteroid use in the setting of infectious keratitis has been a controversial issue. The aim of this review is to provide an update on the evidence for use of topical corticosteroids in addition to antibiotics in bacterial keratitis.Recent findingsJudicious use of steroids is postulated to limit the inflammatory component of bacterial keratitis, but can theoretically retard healing. Three small randomized controlled trials and one large-scale trial, the Steroids for Corneal Ulcers Trial, have provided the most recent evidence to address this debate. Adjunctive topical corticosteroids initiated after at least 48 h of antibiotic usage in cases of culture-proven bacterial keratitis appear generally safe in the treatment of bacterial keratitis. They may be beneficial in cases of severe ulcers especially when initiated early in the course of the infection, in non-Nocardia ulcers, and in certain Pseudomonas ulcers.SummarySeveral randomized controlled trials have greatly contributed to our understanding of the controversy over steroid use in the management of bacterial keratitis. Future studies are needed to confirm subgroup analysis findings and define optimal timing, dosage, and the most appropriate treatment populations.
وصف الملف: application/pdf
اللغة: English
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c688a41a7d393d1aed3a0294a7901ff
https://europepmc.org/articles/PMC6038813/
Rights: OPEN
رقم الانضمام: edsair.doi.dedup.....3c688a41a7d393d1aed3a0294a7901ff
قاعدة البيانات: OpenAIRE