Effects of intracerebroventricularly injected glucagon-like peptide-2 on ethanol-induced gastric mucosal damage in rats
| العنوان: | Effects of intracerebroventricularly injected glucagon-like peptide-2 on ethanol-induced gastric mucosal damage in rats |
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| المؤلفون: | Naciye Isbil-Buyukcoskun, Betul Cam, Kasim Ozluk, Guldal Gulec Suyen |
| المصدر: | Endocrine Research. 43:220-227 |
| بيانات النشر: | Informa UK Limited, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.drug_class, Calcitonin Gene-Related Peptide, medicine.medical_treatment, Calcitonin gene-related peptide, Pharmacology, Nitric oxide, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Glucagon-Like Peptide 2, medicine, Animals, Rats, Wistar, Saline, Injections, Intraventricular, Ethanol, biology, digestive, oral, and skin physiology, General Medicine, Receptor antagonist, Glucagon-like peptide-2, Peptide Fragments, Rats, NG-Nitroarginine Methyl Ester, 030104 developmental biology, chemistry, Gastric Mucosa, Calcitonin, biology.protein, Cyclooxygenase, 030217 neurology & neurosurgery |
| الوصف: | Purpose The present study aims to investigate the effects of intracerebroventricularly (i.c.v.)-injected glucagon-like peptide-2 (GLP-2) on ethanol-induced gastric mucosal damage and to reveal the mechanisms involved in this effect. Materials and methods Rats received absolute ethanol orally via an orogastric tube 30 minutes after GLP-2 (1-200 ng/10 µl; i.c.v.) or saline (10 µl) injections. They were decapitated 1 hour later, their stomachs were removed, and the gastric mucosal damage was scored. Results A total of 100 ng GLP-2 inhibited the gastric mucosal damage by 67%. This effect was abolished by the calcitonin gene-related peptide (CGRP) receptor antagonist CGRP-(8-37) (10 µg/kg; s.c.), but was not affected by either the nitric oxide (NO) synthase inhibitor L-NAME (30 mg/kg; s.c.) or the cyclooxygenase inhibitor indomethacin (5 mg/kg; i.p.). The most effective gastroprotective dose of GLP-2 (100 ng/10 µl; i.c.v.), but not the higher doses (150 or 200 ng/10 µl; i.c.v.) prevented the decrease in gastric mucosal blood flow caused by ethanol. In conclusion, i.c.v. GLP-2 protects against ethanol-induced gastric mucosal damage and this effect is mediated by CGRP receptor activation and gastric mucosal blood flow, but not by NO or prostaglandins. |
| تدمد: | 1532-4206 0743-5800 |
| DOI: | 10.1080/07435800.2018.1460604 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bc9d19336f0d123fa5509a7abf70864 https://doi.org/10.1080/07435800.2018.1460604 |
| رقم الانضمام: | edsair.doi.dedup.....3bc9d19336f0d123fa5509a7abf70864 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15324206 07435800 |
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| DOI: | 10.1080/07435800.2018.1460604 |