Use of sorbitol as pharmaceutical excipient in the present day formulations – issues and challenges for drug absorption and bioavailability
| العنوان: | Use of sorbitol as pharmaceutical excipient in the present day formulations – issues and challenges for drug absorption and bioavailability |
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| المؤلفون: | Ranjeet Prasad Dash, R. Jayachandra Babu, Nuggehally R. Srinivas |
| المصدر: | Drug Development and Industrial Pharmacy. 45:1421-1429 |
| بيانات النشر: | Informa UK Limited, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Drug, Drug Compounding, media_common.quotation_subject, Administration, Oral, Biological Availability, Pharmaceutical Science, Excipient, 02 engineering and technology, Pharmacology, 030226 pharmacology & pharmacy, Excipients, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Pharmacokinetics, Drug Discovery, medicine, Humans, Sorbitol, Theophylline, Cimetidine, Sugar alcohol, media_common, chemistry.chemical_classification, Organic Chemistry, 021001 nanoscience & nanotechnology, Bioavailability, carbohydrates (lipids), chemistry, Gastrointestinal Absorption, Charcoal, Delayed-Action Preparations, 0210 nano-technology, medicine.drug |
| الوصف: | Sorbitol is a popular sugar alcohol which has been used as an excipient in formulations of various drugs. Although from a safety perspective the presence of sorbitol in drug formulations does not raise a concern, reports have emerged and these suggest that sorbitol in drug formulations may alter oral absorption and bioavailability of certain drugs. The focus of this article was to review the published literature of various drugs where pharmacokinetic data has been reported for the drug alone versus drug administered with sorbitol and provide perspectives on the pharmacokinetic findings. Interestingly, for BCS class I drugs such as theophylline, metoprolol, the oral absorption, and bioavailability were generally not affected by sorbitol. However, theophylline oral absorption and bioavailability were decreased when sustained release formulation was used in place of immediate release formulation. For drugs such as risperidone (BCS class II) and lamivudine and ranitidine (BCS class III), the solution formulations showed diminished oral bioavailability in presence of sorbitol, whereas cimetidine and acyclovir (BCS class III), did not show any changes in pharmacokinetic profiles due to sorbitol. Finally, the presence of activated charcoal with sorbitol showed different pharmacokinetic outcome for BCS class I and II drugs. |
| تدمد: | 1520-5762 0363-9045 |
| DOI: | 10.1080/03639045.2019.1640722 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba54ee10d11e1631d3eea22de67eb51 https://doi.org/10.1080/03639045.2019.1640722 |
| رقم الانضمام: | edsair.doi.dedup.....3ba54ee10d11e1631d3eea22de67eb51 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15205762 03639045 |
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| DOI: | 10.1080/03639045.2019.1640722 |