Nut Consumption and Survival in Patients With Stage III Colon Cancer: Results From CALGB 89803 (Alliance)
| العنوان: | Nut Consumption and Survival in Patients With Stage III Colon Cancer: Results From CALGB 89803 (Alliance) |
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| المؤلفون: | Edward Giovannucci, Renaud Whittom, Kimmie Ng, Alan P. Venook, Rex B. Mowat, Al B. Benson, Daniel Atienza, Walter C. Willett, Leonard B. Saltz, Alexander Hantel, Michael J. Messino, Hedy L. Kindler, Robert J. Mayer, Sui Zhang, Ying Bao, Xing Ye, Shuji Ogino, Kana Wu, Charles S. Fuchs, Jeffrey A. Meyerhardt, Donna Niedzwiecki, Temidayo Fadelu |
| المصدر: | Journal of Clinical Oncology |
| بيانات النشر: | American Society of Clinical Oncology, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 2. Zero hunger, Cancer Research, medicine.medical_specialty, business.industry, Colorectal cancer, Hazard ratio, Type 2 diabetes, ORIGINAL REPORTS, medicine.disease, Lower risk, Obesity, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, Internal medicine, Glycemic load, Gastrointestinal Cancer, medicine, 030212 general & internal medicine, Metabolic syndrome, business, Prospective cohort study |
| الوصف: | PurposeObservational studies have reported increased colon cancer recurrence and mortality in patients with states of hyperinsulinemia, including type 2 diabetes, obesity, sedentary lifestyle, and high glycemic load diet. Nut intake has been associated with a lower risk of type 2 diabetes, metabolic syndrome, and insulin resistance. However, the effect of nut intake on colon cancer recurrence and survival is not known.Patients and MethodsWe conducted a prospective, observational study of 826 eligible patients with stage III colon cancer who reported dietary intake on food frequency questionnaires while enrolled onto a randomized adjuvant chemotherapy trial. Using Cox proportional hazards regression, we assessed associations of nut intake with cancer recurrence and mortality.ResultsAfter a median follow-up of 6.5 years, compared with patients who abstained from nuts, individuals who consumed two or more servings of nuts per week experienced an adjusted hazard ratio (HR) for disease-free survival of 0.58 (95% CI, 0.37 to 0.92; Ptrend= .03) and an HR for overall survival of 0.43 (95% CI, 0.25 to 0.74; Ptrend= .01). In subgroup analysis, the apparent benefit was confined to tree nut intake (HR for disease-free survival, 0.54; 95% CI, 0.34 to 0.85; Ptrend= .04; and HR for overall survival, 0.47; 95% CI, 0.27 to 0.82; Ptrend= .04). The association of total nut intake with improved outcomes was maintained across other known or suspected risk factors for cancer recurrence and mortality.ConclusionDiets with a higher consumption of nuts may be associated with a significantly reduced incidence of cancer recurrence and death in patients with stage III colon cancer. |
| اللغة: | English |
| تدمد: | 1527-7755 0732-183X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b5ebd0761ed7d570ccd5344bffce681 http://europepmc.org/articles/PMC5891130 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3b5ebd0761ed7d570ccd5344bffce681 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15277755 0732183X |
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