Reproductive Toxicity of Theobroma cacao: Increase in Survival Index, Nongenotoxic, and Proimplantation Potential
| العنوان: | Reproductive Toxicity of Theobroma cacao: Increase in Survival Index, Nongenotoxic, and Proimplantation Potential |
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| المؤلفون: | Benoit Banga N'guessan, Isaac Julius Asiedu-Gyekye, S. I. Kamalova, V A Grgoreva, Kennedy Kwami Edem Kukuia, Seth Kwabena Amponsah, T. G. Borovskaya, A A Kwapong, А.V. Vychuzhanina, L Allotey Babington, Patrick Amoateng, Y А Shchemerovа, M. E. Poluektova |
| المصدر: | Journal of Toxicology Journal of Toxicology, Vol 2021 (2021) |
| بيانات النشر: | Hindawi Limited, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Pharmacology, 0303 health sciences, Pregnancy, Kidney, Article Subject, Theobroma, Physiology, Biology, Toxicology, medicine.disease, biology.organism_classification, Comet assay, 03 medical and health sciences, 0302 clinical medicine, Therapeutic index, medicine.anatomical_structure, Oral administration, RA1190-1270, Toxicology. Poisons, medicine, Reproductive toxicity, Survival index, 030217 neurology & neurosurgery, Research Article, 030304 developmental biology |
| الوصف: | Unsweetened natural cocoa (UNCP) was evaluated for reproductive toxicity in rats. A preliminary genotoxic potential was evaluated by the DNA comet assay test using C57Bl/6 mice. Both therapeutic dose (TD; 900 mg/kg) and high dose (HD; 9000 mg/kg) of UNCP were used. White Wistar rats were used in two experimental groups. The females received UNCP 15 days before crossing with untreated males. The males received UNCP for 48 days before mating with untreated females. Subacute toxicity was observed during a 14-day oral administration of UNCP. Results show that a high tail DNA% was observed with methyl mesylate administration in all tissues analysed. The lowest tail DNA% value was observed in the liver (1.64 ± 0.26) and kidney (1.63 ± 0.30) during UNCP (TD) administration. UNCP did not induce observable physical congenital malformations on the pubs of treated female and male rats, lacks genotoxic potential, and did not adversely affect pregnancy index, pub weights, and survival index, but UNCP exhibited proimplantation potential ( p > 0.05 ). |
| وصف الملف: | text/xhtml |
| تدمد: | 1687-8205 1687-8191 |
| DOI: | 10.1155/2021/6114672 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aa29a415f1725ec8c3694af05103445 https://doi.org/10.1155/2021/6114672 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3aa29a415f1725ec8c3694af05103445 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16878205 16878191 |
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| DOI: | 10.1155/2021/6114672 |