Higher extracellular fluid volume in women is concealed by scaling to body surface area
| العنوان: | Higher extracellular fluid volume in women is concealed by scaling to body surface area |
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| المؤلفون: | Nagabhushan Seshadri, Claire A. Hooker, Andrew Irwin, A. Michael Peters, Mark C. Barnfield, Ravin Sobnack, Surendra Dave, Mark D. J. Neilly, Thomas Grüning, Richard S. Lawson, Nigel Williams, Bethany Howard, Hayley Snelling, Laura Perry, Neva H. Patel, Gregory Shabo |
| المصدر: | Scandinavian Journal of Clinical and Laboratory Investigation. 73:546-552 |
| بيانات النشر: | Informa UK Limited, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Body Surface Area, Clinical Biochemistry, Body water, Urology, Renal function, Kidney transplant, Body Mass Index, Reference Values, Ratio method, Internal medicine, Extracellular fluid, Living Donors, medicine, Humans, Scaling, Body surface area, Sex Characteristics, Chemistry, Body Weight, Extracellular Fluid, General Medicine, Middle Aged, Kidney Transplantation, Endocrinology, Body Composition, Lean body mass, Female, Algorithms, Glomerular Filtration Rate |
| الوصف: | The objective was to assess body surface area (BSA) for scaling extracellular fluid volume (ECV) in comparison with estimated lean body mass (LBM) and total body water (TBW) across a range of body mass indices (BMI).This was a multi-centre study from 15 centres that submitted raw data from routine measurement of GFR in potential kidney transplant donors. There were 819 men and 1059 women in total. ECV was calculated from slope-intercept and slope-only measurements of GFR. ECV was scaled using two methods: Firstly, division of ECV by the scaling variable (ratio method), and secondly the regression method of Turner and Reilly. Subjects were placed into five BMI groups:20, 20-24.9, 25-29.9, 30-34.9, and 35 + kg/m(2). LBM and TBW were estimated from previously published, gender-specific prediction equations.Ratio and regression scaling gave almost identical results. ECV scaled to BSA by either method was higher in men in all BMI groups but ECV scaled to LBM and TBW was higher in women. There was, however, little difference between men and women in respect to ECV per unit weight in any BMI group, even though women have 10% more adipose tissue. The relations between TBW and BSA and between LBM and BSA, but not between LBM and TBW, were different between men and women.Lean tissue in women contains more extracellular water than in men, a difference that is obscured by scaling to BSA. The likely problem with BSA is its insensitivity to body composition. |
| تدمد: | 1502-7686 0036-5513 |
| DOI: | 10.3109/00365513.2013.819524 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a9955ac43d95a41526654f94b31d470 https://doi.org/10.3109/00365513.2013.819524 |
| رقم الانضمام: | edsair.doi.dedup.....3a9955ac43d95a41526654f94b31d470 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15027686 00365513 |
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| DOI: | 10.3109/00365513.2013.819524 |