Dissecting Arabidopsis Gβ Signal Transduction on the Protein Surface
| العنوان: | Dissecting Arabidopsis Gβ Signal Transduction on the Protein Surface |
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| المؤلفون: | Yuri Trusov, Fitzgerald L. Booker, Arwen Frick-Cheng, Antonio Molina, David M. Rosenthal, Alan M. Jones, Kun Jiang, Ralph Panstruga, José Ramón Botella, Donald R. Ort, Magdalena Delgado-Cerezo, Justine Lorek |
| المصدر: | Plant Physiology, ISSN 0032-0889, 2012-07, Vol. 159, No. 3 Archivo Digital UPM Universidad Politécnica de Madrid |
| بيانات النشر: | Oxford University Press (OUP), 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | 2. Zero hunger, 0106 biological sciences, 0303 health sciences, Physiology, Biología, Mutant, Mutagenesis (molecular biology technique), Plant Science, Biology, biology.organism_classification, 01 natural sciences, Phenotype, Cell biology, 03 medical and health sciences, Cytoplasm, Heterotrimeric G protein, Arabidopsis, Botany, Genetics, Arabidopsis thaliana, Signal transduction, 030304 developmental biology, 010606 plant biology & botany |
| الوصف: | The heterotrimeric G-protein complex provides signal amplification and target specificity. The Arabidopsis (Arabidopsis thaliana) Gβ-subunit of this complex (AGB1) interacts with and modulates the activity of target cytoplasmic proteins. This specificity resides in the structure of the interface between AGB1 and its targets. Important surface residues of AGB1, which were deduced from a comparative evolutionary approach, were mutated to dissect AGB1-dependent physiological functions. Analysis of the capacity of these mutants to complement well-established phenotypes of Gβ-null mutants revealed AGB1 residues critical for specific AGB1-mediated biological processes, including growth architecture, pathogen resistance, stomata-mediated leaf-air gas exchange, and possibly photosynthesis. These findings provide promising new avenues to direct the finely tuned engineering of crop yield and traits. |
| وصف الملف: | application/pdf |
| تدمد: | 1532-2548 |
| DOI: | 10.1104/pp.112.196337 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a90fb0c72706047da3aecd5e3d2f767 https://doi.org/10.1104/pp.112.196337 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3a90fb0c72706047da3aecd5e3d2f767 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15322548 |
|---|---|
| DOI: | 10.1104/pp.112.196337 |