Protective efficacies of live attenuated and formaldehyde-inactivated Venezuelan equine encephalitis virus vaccines against aerosol challenge in hamsters
| العنوان: | Protective efficacies of live attenuated and formaldehyde-inactivated Venezuelan equine encephalitis virus vaccines against aerosol challenge in hamsters |
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| المؤلفون: | P B Jahrling, E H Stephenson |
| المصدر: | Journal of Clinical Microbiology. 19:429-431 |
| بيانات النشر: | American Society for Microbiology, 1984. |
| سنة النشر: | 1984 |
| مصطلحات موضوعية: | Encephalomyelitis, Equine, Male, Microbiology (medical), INVESTIGATIONAL VACCINES, Virulence, Vaccines, Attenuated, medicine.disease_cause, complex mixtures, Encephalitis Virus, Venezuelan Equine, Cricetinae, Formaldehyde, medicine, Animals, Aerosols, Attenuated vaccine, Mesocricetus, biology, business.industry, Encephalomyelitis, Venezuelan Equine, Viral Vaccines, Venezuelan equine encephalomyelitis virus, Virology, Venezuelan equine encephalomyelitis, Venezuelan equine encephalitis virus, biology.protein, Immunization, Viral disease, Antibody, business, Research Article |
| الوصف: | Although two investigational vaccines are used to immunize humans against Venezuelan equine encephalomyelitis virus, neither had previously been tested for protective efficacy against aerosol exposure. Live attenuated vaccine (TC-83) protected all hamsters challenged by either aerosol or subcutaneous routes with 4.7 to 5.2 log10 PFU of virulent Venezuelan equine encephalomyelitis virus. Formaldehyde-inactivated vaccine (C-84) failed to protect against aerosol challenge but did protect against subcutaneous challenge. Protection elicited by TC-83 vaccine did not depend solely on serum-neutralizing antibody. These studies suggest that TC-83 vaccine is preferable to C-84 vaccine for protecting laboratory workers at risk to aerosol exposure. |
| تدمد: | 1098-660X 0095-1137 |
| DOI: | 10.1128/jcm.19.3.429-431.1984 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a6f9fd928ef7626ea615afeaeba2e53 https://doi.org/10.1128/jcm.19.3.429-431.1984 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3a6f9fd928ef7626ea615afeaeba2e53 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1098660X 00951137 |
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| DOI: | 10.1128/jcm.19.3.429-431.1984 |