التفاصيل البيبلوغرافية
العنوان:
Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis
المؤلفون:
Benedicte Jachez-Demange , Joerg Eder , Roland Feifel , Rudolf Waelchli , Achim Schlapbach , Thomas Buhl , Helmut Sparrer , Pius Loetscher , Laszlo Revesz , Ronald Esser , Richard Heng , Birgit Bollbuck , Peter Hiestand
المصدر:
Bioorganic & Medicinal Chemistry Letters . 15:5160-5164
بيانات النشر:
Elsevier BV, 2005.
سنة النشر:
2005
مصطلحات موضوعية:
CCR1 , Ratón , Clinical Biochemistry , Receptors, CCR1 , Administration, Oral , Pharmaceutical Science , Arthritis , Pharmacology , Biochemistry , Mice , Structure-Activity Relationship , Pharmacokinetics , Oral administration , Drug Discovery , medicine , Animals , Humans , Receptor , Molecular Biology , chemistry.chemical_classification , Chemistry , Anti-Inflammatory Agents, Non-Steroidal , Organic Chemistry , Antagonist , medicine.disease , Arthritis, Experimental , Rats , Molecular Medicine , Receptors, Chemokine , Glycoprotein
الوصف:
Cinnamides as novel CCR1 antagonist chemotypes are described with high affinity to human and rodent receptors. A1B1 and A4B7 showed oral activity in the mouse collagen induced arthritis.
تدمد:
0960-894X
DOI:
10.1016/j.bmcl.2005.08.057
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a518df51d3c61422d5d2c1e0a844651 https://doi.org/10.1016/j.bmcl.2005.08.057
Rights:
CLOSED
رقم الانضمام:
edsair.doi.dedup.....3a518df51d3c61422d5d2c1e0a844651
قاعدة البيانات:
OpenAIRE