Chronic abruption-oligohydramnios sequence (CAOS) revisited: possible implication of premature rupture of membranes
| العنوان: | Chronic abruption-oligohydramnios sequence (CAOS) revisited: possible implication of premature rupture of membranes |
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| المؤلفون: | Ken Yamaguchi, Yasuhisa Kurata, Masaki Mandai, Sachiko Minamiguchi, Kaoru Kawasaki, Akihito Horie, Aki Kido, Eriko Yasuda, Ayami Ishida, Eiji Kondoh, Yoshitsugu Chigusa, Haruta Mogami |
| المصدر: | The Journal of Maternal-Fetal & Neonatal Medicine. 35:6894-6900 |
| بيانات النشر: | Informa UK Limited, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Fetal Membranes, Premature Rupture, Placenta, Oligohydramnios, Bioinformatics, Necrosis, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, medicine, Humans, Retrospective Studies, Sequence (medicine), Hematoma, 030219 obstetrics & reproductive medicine, business.industry, Infant, Newborn, Obstetrics and Gynecology, Syndrome, Amniotic Fluid, medicine.disease, 030104 developmental biology, Pediatrics, Perinatology and Child Health, Premature Birth, Subchorionic hematoma, Female, business, Premature rupture of membranes |
| الوصف: | The pathogenic mechanism of chronic abruption-oligohydramnios sequence (CAOS) remains unknown, and there are no objective standards for diagnosis on imaging or using pathological evidence. We aimed to reconsider and clarify the true pathology of CAOS by integrating clinical, magnetic resonance imaging (MRI) and histopathological findings of the placenta.This is a case series of patients with CAOS managed at our hospital between 2010 and 2020. The clinical data of the patients, including MRI findings and placental pathology, were reviewed retrospectively.A total of 18 patients were eligible. Preterm birth occurred in 17 (94%) cases; the median gestational age at delivery was 25. Three neonates (17%) died within two years, and 10 neonates (56%) developed chronic lung disease. MRI was performed in 13 cases and clearly showed intrauterine hematoma and hemorrhagic amniotic fluid. Pathologically, in all cases, retroplacental hematoma was not detected, and fetal membranes were extremely fragile and ragged. Shedding and necrosis of the amniotic epithelium was a characteristic finding, which was confirmed in 17 cases (94%). Diffuse chorionic hemosiderosis (DCH) was detected in all cases.The fundamental cause of CAOS is repeated intrauterine hemorrhage and subsequent subchorionic hematoma, which induces hemorrhagic amniotic fluid and DCH. Consequently, these factors result in the necrosis and weakening of the amnion. Therefore, the true pathology of CAOS is believed to be premature rupture of membranes rather than chronic abruption. |
| تدمد: | 1476-4954 1476-7058 |
| DOI: | 10.1080/14767058.2021.1929159 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a1a22ff877c826e67af4691e374101c https://doi.org/10.1080/14767058.2021.1929159 |
| رقم الانضمام: | edsair.doi.dedup.....3a1a22ff877c826e67af4691e374101c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14764954 14767058 |
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| DOI: | 10.1080/14767058.2021.1929159 |