High incidence of acute lung injury in children with Down syndrome
| العنوان: | High incidence of acute lung injury in children with Down syndrome |
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| المؤلفون: | L. B. van der Aa, Martijn Bruijn, J.B.M. van Woensel, Albert P. Bos, R.R. van Rijn |
| المساهمون: | Amsterdam institute for Infection and Immunity, Other Research, General Paediatrics, Paediatric Pulmonology, Radiology and Nuclear Medicine, Paediatric Intensive Care, Amsterdam Reproduction & Development (AR&D) |
| المصدر: | Intensive care medicine, 33(12), 2179-2182. Springer Verlag Intensive Care Medicine |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, ARDS, Epidemiology, Down syndrome, Lung injury, Critical Care and Intensive Care Medicine, Cohort Studies, Mechanical ventilation, Internal medicine, Intensive care, medicine, Humans, Pediatric Brief Report, Child, Diffuse alveolar damage, Netherlands, Retrospective Studies, Respiratory Distress Syndrome, Acute respiratory distress syndrome, Respiratory distress, business.industry, Incidence, Incidence (epidemiology), Respiratory disease, Infant, Newborn, Infant, Retrospective cohort study, medicine.disease, Respiration, Artificial, respiratory tract diseases, Surgery, Child, Preschool, Female, business |
| الوصف: | Objective: Acute respi- ratory tract infection is a common reason for hospitalization in children with Down syndrome (CDS) and is characterized by a high morbidity. The severe course of disease in CDS may be related to a higher incidence of acute lung injury (ALI). This study evaluated the incidence of ALI and acute respiratory distress syndrome (ARDS) in mechanically ventilated CDS. Design and setting: Retrospec- tive cohort study in a pediatric ICU. Patients and participants: Cases were all mechanically ventilated CDS admitted to our unit between January 1998 and July 2005. All mechanically ventilated patients without Down syn- drome from January 1998 to January 2001 served as controls. Postopera- tive patients (cases and controls) and those with a cardiac left to right shunt were excluded. Measurements and results: The main outcome measure was the incidence of ALI and ARDS. The criteria for ALI were met in 14 of 24 CDS (58.3%) in 41 of 317 of controls (12.9%; OR 9.4, 95% CI 3.9-22.6). The criteria for ARDS were met in 11 of 24 CDS (46%) and in 21 of 317 of controls (7%;OR 11.9, 95% CI 4.8-29.8). None of the CDS with ALI died; in the control group ten patients with ALI died. Conclu- sions: CDS had a significantly higher incidence of ALI and ARDS than children without Down syndrome. The explanation for this remains to be elucidated; further study is necessary before clinical implications become clear. |
| اللغة: | English |
| تدمد: | 0342-4642 |
| DOI: | 10.1007/s00134-007-0803-z |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39fefb765cf1ceaf639fa6cc41b53d2b https://doi.org/10.1007/s00134-007-0803-z |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....39fefb765cf1ceaf639fa6cc41b53d2b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 03424642 |
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| DOI: | 10.1007/s00134-007-0803-z |