Single-step pulsed electrodeposition of calcium phosphate coatings on titanium for drug delivery
| العنوان: | Single-step pulsed electrodeposition of calcium phosphate coatings on titanium for drug delivery |
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| المؤلفون: | Sophie Cazalbou, Christèle Combes, José María Manero, Judit Buxadera-Palomero, Elia Vidal, Daniel Rodríguez, Camille Pierre, Elisa Rupérez, Maria-Pau Ginebra |
| المساهمون: | Centre National de la Recherche Scientifique - CNRS (FRANCE), Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE), Université Toulouse III - Paul Sabatier - UT3 (FRANCE), Universitat Politècnica de Catalunya - UPC (SPAIN), Centre Interuniversitaire de Recherche et d'Ingénierie des Matériaux - CIRIMAT (Toulouse, France), Institut National Polytechnique de Toulouse - INPT (FRANCE), Universitat Politècnica de Catalunya [Barcelona] (UPC), Centre interuniversitaire de recherche et d'ingenierie des matériaux (CIRIMAT), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC), Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica, Universitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits |
| المصدر: | Surface and Coatings Technology Surface and Coatings Technology, Elsevier, 2019, 358, pp.266-275. ⟨10.1016/j.surfcoat.2018.11.037⟩ UPCommons. Portal del coneixement obert de la UPC Universitat Politècnica de Catalunya (UPC) Recercat. Dipósit de la Recerca de Catalunya instname |
| بيانات النشر: | Elsevier, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Materials science, Characterization, Matériaux, Kinetics, chemistry.chemical_element, Single step, 02 engineering and technology, Electrolyte, Calcium, Enginyeria dels materials [Àrees temàtiques de la UPC], 010402 general chemistry, medicine.disease_cause, 01 natural sciences, [SPI.MAT]Engineering Sciences [physics]/Materials, Coating, Fosfat de calci -- Aplicacions mèdiques, Materials Chemistry, medicine, Tissue engineering, Pulse electrodeposition, Antibacterial agent, Titanium, [CHIM.MATE]Chemical Sciences/Material chemistry, Surfaces and Interfaces, General Chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 0104 chemical sciences, Surfaces, Coatings and Films, Calcium phosphate, Enginyeria de teixits, chemistry, Calcium phosphates, Titani -- Aplicacions mèdiques, Materials biomèdics, Staphylococcus aureus, Drug delivery, 0210 nano-technology, Biomedical materials, Pulse électrodeposition, Nuclear chemistry |
| الوصف: | International audience; Metallic implants have some limitations related to bioactivity and bacteria colonization leading to infections. In this regard, calcium phosphate coatings can be used as carrier for drug delivery in order to improve the mentioned drawbacks. The present work proposes the introduction of an antibacterial agent in the course of a pulsed and reverse pulsed electrodeposition. Calcium phosphate coatings were prepared in 30min using different pulse waveforms (unipolar-bipolar), current densities (2–5mA/cm2) and temperatures (40–60°C). Mechanical stability of the as-coated surfaces was studied in order to select the optimal electrodeposition conditions. Subsequently, selected coatings were loaded with an antiseptic agent, chlorhexidine digluconate (CHX), via a single-step co-deposition procedure. CHX concentration added to the electrolyte was adjusted to 3mM based on the antibacterial efficacy of the loaded coatings evaluated in vitro with Staphylococcus aureus and Escherichia coli bacteria strains. Whereasthe same chlorhexidineconcentration was addedto the electrolyte, results showedthat the amount of CHX loaded was different for each condition while release kinetics was maintained. The results of this work demonstrate that a pulsed co-deposition strategy has great potential to modulate local delivery of antibacterial agents such as chlorhexidine digluconate, which may prevent early phase infections of metallic implants after insertion. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0257-8972 |
| DOI: | 10.1016/j.surfcoat.2018.11.037⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f866ccc334a0df818541f6d4877279 https://oatao.univ-toulouse.fr/24054/ |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....39f866ccc334a0df818541f6d4877279 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 02578972 |
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| DOI: | 10.1016/j.surfcoat.2018.11.037⟩ |