The distinct epidemic characteristics of HCV co-infection among HIV-1-infected population caused by drug injection and sexual transmission in Yunnan, China
| العنوان: | The distinct epidemic characteristics of HCV co-infection among HIV-1-infected population caused by drug injection and sexual transmission in Yunnan, China |
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| المؤلفون: | Ling-Shuai Jiao, Mi Zhang, Xingqi Dong, Li Gao, Yue Feng, A-Mei Zhang, Xueshan Xia, Ming Yang |
| المصدر: | Epidemiology and Infection |
| بيانات النشر: | Cambridge University Press (CUP), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, China, Sexual transmission, Genotype, Epidemiology, Hepatitis C virus, Human immunodeficiency virus (HIV), HIV Infections, Hepacivirus, medicine.disease_cause, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Biochemical features, Disease Transmission, Infectious, Prevalence, Humans, Medicine, Epidemics, Substance Abuse, Intravenous, Infected population, NS5B, HCV/HIV co-infection, Drug injection, Original Paper, Coinfection, business.industry, virus diseases, Middle Aged, Viral Load, Hepatitis C, Virology, digestive system diseases, 030104 developmental biology, Infectious Diseases, chemistry, Female, 030211 gastroenterology & hepatology, business, Co infection |
| الوصف: | Hepatitis C virus (HCV) infection was frequent in human immunodeficiency virus (HIV) patients in Yunnan province. We studied the epidemic characteristics of HCV in HIV/HCV co-infected patients. Serum from 894 HIV-1 patients was collected, together with basic information and biochemical features. All samples were infected with HIV through injecting drug users (IDUs) and sexual transmission (ST). The NS5B gene was amplified and sequenced to affirm HCV genotype. In total, 202 HIV patients were co-infected with HCV, and most (81.19%) of co-infected patients were IDUs. Genotype 3b was predominant (37.62%) in these samples, and its frequency was similar in patients with IDU and ST. The frequencies of genotypes 1a, 1b, 3a, 6a, 6n, 2a and 6u were 3.96%, 16.34%, 23.76%, 6.93%, 10.40%, 0.50% and 0.50%, respectively. However, genotype 3a showed significantly different frequency in HCV patients with IDU and ST (P = 0.019). When HCV patients were divided into subgroups, the haemoglobin (HGB) level was significantly higher in patients with genotype 3a than in patients with 3b (P = 0.033), 6a (P = 0.006) and 6n (P = 0.007), respectively. Although no difference existed among HCV subgroups, HIV-viral load was identified to be positively correlated with the HGB level and CD4+ cells when dividing HCV/HIV co-infected persons into male and female groups. In conclusion, genotype 3b was the predominant HCV genotype in Yunnan HIV/HCV co-infected persons. The HGB level was higher in patients with genotype 3a than others. HIV-viral load was positively correlated with the HGB level and CD4+ cells in the male or female HCV-infected group. |
| تدمد: | 1469-4409 0950-2688 |
| DOI: | 10.1017/s0950268819001365 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f579ece7cf69eb864e3fcb1dd76959 https://doi.org/10.1017/s0950268819001365 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....39f579ece7cf69eb864e3fcb1dd76959 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14694409 09502688 |
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| DOI: | 10.1017/s0950268819001365 |