Hepatocellular Carcinoma in Cirrhotic and Noncirrhotic Livers:A Clinico-Histopathologic Study of 804 North American Patients
| العنوان: | Hepatocellular Carcinoma in Cirrhotic and Noncirrhotic Livers:A Clinico-Histopathologic Study of 804 North American Patients |
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| المؤلفون: | Kamal G. Ishak, Zachary Goodman, Ugochukwu C. Nzeako |
| المصدر: | American Journal of Clinical Pathology. 105:65-75 |
| بيانات النشر: | Oxford University Press (OUP), 1996. |
| سنة النشر: | 1996 |
| مصطلحات موضوعية: | Adult, Liver Cirrhosis, Male, medicine.medical_specialty, Carcinoma, Hepatocellular, Cirrhosis, Adolescent, Alcohol Drinking, Aspartate transaminase, Gastroenterology, Hepatitis, Liver Function Tests, Internal medicine, Epidemiology, Prevalence, medicine, Carcinoma, Humans, Child, Survival rate, Aged, Aged, 80 and over, medicine.diagnostic_test, biology, business.industry, Liver Neoplasms, General Medicine, Middle Aged, Prognosis, medicine.disease, Survival Rate, Natural history, Liver, Child, Preschool, Hepatocellular carcinoma, Chronic Disease, North America, biology.protein, Female, Liver function tests, business |
| الوصف: | This study examined clinico-histopathologic differences between North American patients who developed hepatocellular carcinoma with and without cirrhosis. Histologic slides and clinical records of cases were reviewed. Cases were classified according to defined histopathologic criteria. Analyses were performed using appropriate tests. A total of 42.6% of cases were noncirrhotic. The trabecular type of hepatocellular carcinoma was the most common growth pattern in both groups. Patients with cirrhosis were significantly older, had high grade tumors, and local portal venous invasion significantly more often than patients without cirrhosis. Encapsulated tumors occurred in significantly more in patients without cirrhosis. Patients without cirrhosis survived longer than patients with cirrhosis (P < .0001) and had a better 5-year survival experience. On average, in patients with cirrhosis, serum aspartate transaminase and total serum bilirubin were significantly greater, and serum albumin was significantly lower. In general, hepatocellular carcinoma in North American patients with cirrhosis tended to be less well differentiated than those found among patients without cirrhosis. The pathology, natural history, and prognosis of this tumor is significantly influenced by the presence or absence of cirrhosis in the nonneoplastic liver, and the presence of cirrhosis portends a poorer prognosis. |
| تدمد: | 1943-7722 0002-9173 |
| DOI: | 10.1093/ajcp/105.1.65 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ecc542cc7bec1ef0be6b884bea1e63 https://doi.org/10.1093/ajcp/105.1.65 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....39ecc542cc7bec1ef0be6b884bea1e63 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19437722 00029173 |
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| DOI: | 10.1093/ajcp/105.1.65 |