Clinical and epidemiological profile of alloimmunized and autoimmunized multi-transfused patients against red blood cell antigens in a blood center of Minas Gerais
| العنوان: | Clinical and epidemiological profile of alloimmunized and autoimmunized multi-transfused patients against red blood cell antigens in a blood center of Minas Gerais |
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| المؤلفون: | Orsetti Gomes do Valle Neto, Gilberto de Araújo Pereira, Helio Moraes-Souza, Vitor Mendonça Alves, Paulo Roberto Juliano Martins |
| المصدر: | Hematology, Transfusion and Cell Therapy Hematology, Transfusion and Cell Therapy, Vol 40, Iss 2, Pp 107-111 (2018) Hematology, Transfusion and Cell Therapy, Volume: 40, Issue: 2, Pages: 107-111, Published: JUN 2018 |
| بيانات النشر: | Elsevier BV, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | medicine.medical_specialty, 030204 cardiovascular system & hematology, medicine.disease_cause, Autoimmunity, 03 medical and health sciences, 0302 clinical medicine, Antigen, Statistical significance, Internal medicine, Epidemiology, medicine, Immunology and Allergy, Multi-transfused patients, Alloimmunization, lcsh:RC633-647.5, business.industry, Alloimmunity, Autoantibody, Retrospective cohort study, lcsh:Diseases of the blood and blood-forming organs, Hematology, Autoimmunization, Original Article, business, Rh blood group system, Red blood cell antibodies, 030215 immunology |
| الوصف: | Background: The large diversity of red blood cell antigens favors, especially in multi-transfused patients, the occurrence of autoimmunization and alloimmunization with the risk of hemolytic transfusion reactions. Thus, this study aimed to determine the rates of alloimmunization and autoimmunization in these individuals, as well as the types of alloantibodies and their systems, clinical and epidemiological aspects and the frequency of autoimmunity in alloimmunized and non-alloimmunized patients. Methods: In a retrospective study, 153 multi-transfused patients from 2006 to 2014 were evaluated. Sixty-eight had onco-hematological diseases, 64 had hemoglobinopathies and 21 had chronic renal failure. Descriptive analyses were carried out with the proportions being compared using the chi-square test, with the significance level set at 5%. Results: The Rh system was the most frequently involved (53.11%) and anti-E and anti-K (Kell system) were the most prevalent alloantibodies (21.87% each). Autoantibodies were found in ten patients (6.54%) with the percentages of autoimmunization in alloimmunized and non-alloimmunized individuals being 29.16% and 2.32%, respectively (p = 0.0001). There was a significant difference between autoimmunization and the number of transfusions (16.21% in 6–10 vs. 5.26% 10; p = 0.0203) and diseases (19.04% in chronic renal failure vs. 6.25% in hemoglobinopathies vs. 2.94% in onco-hematological diseases; p = 0.0329). Conclusion: The results show a strong correlation between alloimmunization and autoimmunization. Moreover, they reinforce the need for further studies on the clinical and epidemiological profile of multi-transfused patients in relation to alloimmunity and autoimmunity, especially the latter, for a better understanding of its etiopathogenesis and physiopathogenesis. Keywords: Multi-transfused patients, Red blood cell antibodies, Alloimmunization, Autoimmunization |
| وصف الملف: | text/html |
| تدمد: | 2531-1379 |
| DOI: | 10.1016/j.htct.2017.08.001 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b896e7f44eaa67e0a626f103370cb9 https://doi.org/10.1016/j.htct.2017.08.001 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....39b896e7f44eaa67e0a626f103370cb9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25311379 |
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| DOI: | 10.1016/j.htct.2017.08.001 |