Extensive HLA class I allele promiscuity among viral CTL epitopes
| العنوان: | Extensive HLA class I allele promiscuity among viral CTL epitopes |
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| المؤلفون: | John Sidney, Tonia Woodberry, Nicole Frahm, Kaori Sango, Simon Mallal, Eunice Pae, Florian Bihl, Carl M. Kadie, Nebojsa Jojic, Bruce D. Walker, Karina Yusim, Todd J. Suscovich, Alessandro Sette, Peter T. Hraber, Kellie Faircloth, Ashok Khatri, Francesco M. Marincola, Sharon Adams, Daniel G. Kavanagh, Hannah S. Hewitt, Caitlyn Linde, Jennifer Listgarten, Mina John, Christian Brander, Leah M. Henry, M. Tauheed Zaman, Bette T. Korber, Nancy V. Brown, David Heckerman |
| المصدر: | European Journal of Immunology. 37:2419-2433 |
| بيانات النشر: | Wiley, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Genetics, MHC class II, Histocompatibility Antigens Class I, Molecular Sequence Data, Immunology, Antigen presentation, Epitopes, T-Lymphocyte, HIV, Human leukocyte antigen, Biology, Virology, Article, Epitope, Antigen, MHC class I, biology.protein, Humans, Immunology and Allergy, Cytotoxic T cell, Amino Acid Sequence, Allele, Alleles, T-Lymphocytes, Cytotoxic |
| الوصف: | Promiscuous binding of T helper epitopes to MHC class II molecules has been well established, but few examples of promiscuous class I-restricted epitopes exist. To address the extent of promiscuity of HLA class I peptides, responses to 242 well-defined viral epitopes were tested in 100 subjects regardless of the individuals' HLA type. Surprisingly, half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Functional assays confirmed the frequent recognition of HLA class I-restricted T cell epitopes on several alternative alleles across HLA class I supertypes and encoded on different class I loci. These data have significant implications for the understanding of MHC class I-restricted antigen presentation and vaccine development. |
| تدمد: | 1521-4141 0014-2980 |
| DOI: | 10.1002/eji.200737365 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3976035b4412908691a01c52a263159d https://doi.org/10.1002/eji.200737365 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3976035b4412908691a01c52a263159d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15214141 00142980 |
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| DOI: | 10.1002/eji.200737365 |