Stereoselective Synthesis of (−)-Acanthoic Acid
| العنوان: | Stereoselective Synthesis of (−)-Acanthoic Acid |
|---|---|
| المؤلفون: | Michael A. Palladino, Taotao Ling, Bryan A. Kramer, Emmanuel A. Theodorakis |
| المصدر: | Organic Letters. 2:2073-2076 |
| بيانات النشر: | American Chemical Society (ACS), 2000. |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | chemistry.chemical_classification, Korea, Plants, Medicinal, Ketone, Stereochemistry, Anti-Inflammatory Agents, Non-Steroidal, Organic Chemistry, Molecular Conformation, Stereoisomerism, Crystallography, X-Ray, Plant Roots, Biochemistry, Cycloaddition, chemistry, Cyclization, Indicators and Reagents, Stereoselectivity, Diterpenes, Physical and Theoretical Chemistry, Acanthoic acid |
| الوصف: | [reaction: see text] The first stereoselective synthesis of (-)-acanthoic acid (1) has been designed and accomplished. Our synthetic plan departs from (-) Wieland-Miesher ketone (7) and calls upon a Diels-Alder cycloaddition reaction for the construction of the C ring of 1. The described synthesis confirms the proposed stereochemistry of 1 and represents an efficient entry into an unexplored class of biologically active diterpenes. |
| تدمد: | 1523-7052 1523-7060 |
| DOI: | 10.1021/ol0060578 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38a14f645d92a950712b4d65fb13fae0 https://doi.org/10.1021/ol0060578 |
| رقم الانضمام: | edsair.doi.dedup.....38a14f645d92a950712b4d65fb13fae0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15237052 15237060 |
|---|---|
| DOI: | 10.1021/ol0060578 |