Autoimmune polyendocrine syndrome type 2 in patient with severe allergic asthma treated with omalizumab
| العنوان: | Autoimmune polyendocrine syndrome type 2 in patient with severe allergic asthma treated with omalizumab |
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| المؤلفون: | Anna Rams, Weronika Zastrzeżyńska, Agnieszka Serafin, Joanna Wilańska, Stanisław Polański, Stanisława Bazan-Socha, Marek Żółciński, Jacek Musiał |
| المصدر: | Journal of Asthma. 55:1384-1386 |
| بيانات النشر: | Informa UK Limited, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Hypersensitivity, Immediate, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Atrophic gastritis, medicine.medical_treatment, 030209 endocrinology & metabolism, Omalizumab, Disease, Thyroiditis, Primary Adrenal Insufficiency, Targeted therapy, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Immunology and Allergy, Anti-Asthmatic Agents, Polyendocrinopathies, Autoimmune, Asthma, business.industry, Middle Aged, medicine.disease, Dermatology, 030228 respiratory system, Autoimmune polyendocrine syndrome type 2, Pediatrics, Perinatology and Child Health, Female, business, medicine.drug |
| الوصف: | Asthma therapy with monoclonal antibodies is a promising and effective approach for those with a severe and refractory type of disease. Although such a targeted therapy is considered to be safe, unusual complications may occur. We present a case of a 45 year-old female patient with severe allergic asthma and chronic spontaneous urticaria, who developed autoimmune polyendocrine syndrome type 2 (APS-2) after 26 months of omalizumab administration. The patient was diagnosed with primary adrenal insufficiency (Addison's disease) and Hashimoto's thyroiditis accompanied by autoimmune atrophic gastritis. According to our knowledge this is the first description of APS-2 that developed in conjunction with omalizumab treatment, although we have no evidence that the observed phenomenon indicated a cause-effect relationship to omalizumab. |
| تدمد: | 1532-4303 0277-0903 |
| DOI: | 10.1080/02770903.2017.1414239 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3874bf86ef006609b9fc9f001e6dfaf5 https://doi.org/10.1080/02770903.2017.1414239 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3874bf86ef006609b9fc9f001e6dfaf5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15324303 02770903 |
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| DOI: | 10.1080/02770903.2017.1414239 |