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Multitargeted Compounds Derived from (2,5-Dioxopyrrolidin-1-yl)(phenyl)-Acetamides as Candidates for Effective Anticonvulsant and Antinociceptive Agents

التفاصيل البيبلوغرافية
العنوان: Multitargeted Compounds Derived from (2,5-Dioxopyrrolidin-1-yl)(phenyl)-Acetamides as Candidates for Effective Anticonvulsant and Antinociceptive Agents
المؤلفون: Szczepan Mogilski, Annamaria Lubelska, Rafał M. Kamiński, Krzysztof Kamiński, Gniewomir Latacz, Michał Abram, Anna Rapacz
المصدر: ACS chemical neuroscience. 11(13)
سنة النشر: 2020
مصطلحات موضوعية: Pyrrolidines, Physiology, Cognitive Neuroscience, medicine.medical_treatment, Pharmacology, Biochemistry, TRPV, 03 medical and health sciences, Mice, Structure-Activity Relationship, 0302 clinical medicine, Acetamides, Antinociceptive Agents, medicine, Animals, 030304 developmental biology, 0303 health sciences, Analgesics, Electroshock, Molecular Structure, Chemistry, Cell Biology, General Medicine, Disease Models, Animal, Anticonvulsant, Neuropathic pain, Pentylenetetrazole, Anticonvulsants, 030217 neurology & neurosurgery
الوصف: We developed a focused set of original hybrid pyrrolidine-2,5-dione derivatives with potent anticonvulsant and antinociceptive properties. These hybrid compounds demonstrated broad-spectrum protective activity in a range of mouse models, such as the maximal electroshock (MES) test, the pentylenetetrazole-induced seizures (
تدمد: 1948-7193
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37dc0cdb4c2acc51babb4e48281d0654
https://pubmed.ncbi.nlm.nih.gov/32479058
Rights: OPEN
رقم الانضمام: edsair.doi.dedup.....37dc0cdb4c2acc51babb4e48281d0654
قاعدة البيانات: OpenAIRE
الوصف
تدمد:19487193