Beneficial effects of thyroid hormone on adipose inflammation and insulin sensitivity of obese Wistar rats
| العنوان: | Beneficial effects of thyroid hormone on adipose inflammation and insulin sensitivity of obese Wistar rats |
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| المؤلفون: | Ana Carolina Panveloski-Costa, Gabriela Souza Viana, Paula Bargi-Souza, Maria Tereza Nunes, Caroline Serrano-Nascimento, L. L. Poyares |
| المصدر: | Physiological Reports Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| بيانات النشر: | John Wiley and Sons Inc., 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Blood Glucose, Male, medicine.medical_specialty, endocrine system, obesity, endocrine system diseases, Physiology, medicine.medical_treatment, Immunology, Thyroid Gland, Adipose tissue, Thyrotropin, 030209 endocrinology & metabolism, White adipose tissue, Thyroglobulin, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, Thyroid peroxidase, Physiology (medical), Internal medicine, triiodothyronine, Medicine, insulin sensitivity, Animals, Rats, Wistar, GLÂNDULA TIREOIDE, Original Research, Feedback, Physiological, biology, Symporters, business.industry, Thyroid, Receptors, Thyrotropin, medicine.disease, cytokines, Endocrinology and Metabolism, Rats, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, biology.protein, Thyroid function, Insulin Resistance, business, Hormone |
| الوصف: | Thyroid hormones play an important role in glucose metabolism and there is evidence of increased prevalence of thyroid dysfunction in obese and diabetic patients. This study aimed at evaluating the thyroid function and the effects of the triiodothyronine (T3) treatment on glycemia control, insulin sensitivity and subclinical inflammation in cafeteria‐diet‐induced obesity in rats. Obesity was induced in male Wistar rats by offering a cafeteria diet and a subset of the obese rats was treated with T3 (1.5 μg per 100 g of body weight) for a 28‐day period. The pituitary‐thyroid axis was evaluated by molecular and biochemical parameters. Cytokine content was measured in the serum as well as in the mesenteric and epididymal white adipose tissue. Obese rats exhibited impairment of glycemia control, increased content of inflammatory cytokines in mesenteric white adipose tissue, decreased serum thyrotropin (TSH) concentration and increased sodium/iodide symporter (NIS) and TSH receptor (TSHR) protein content in thyroid gland. T3 treatment improved insulin sensitivity, glucose tolerance, and reduced inflammatory cytokine content in mesenteric white adipose tissue. In the thyroid gland NIS, TSHR, and thyroperoxidase (TPO) content were reduced while thyroglobulin (TG) content was increased by T3. The thyrotrophic response to negative feedback exerted by T3 was preserved in obese rats. The present data reinforce the beneficial effects of T3 treatment of obese rats on the improvement of insulin sensitivity and on the negative modulation of inflammatory cytokine expression in adipose tissue. Moreover, we have evidenced that the pituitary‐thyroid axis is affected in obese rats, as illustrated by the impaired TSH secretion. |
| اللغة: | English |
| تدمد: | 2051-817X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::379728ee86a940fa89ea980441e6c93a http://europepmc.org/articles/PMC5817825 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....379728ee86a940fa89ea980441e6c93a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2051817X |
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