Dietary intake of pantothenic acid is associated with cerebral amyloid burden in patients with cognitive impairment
| العنوان: | Dietary intake of pantothenic acid is associated with cerebral amyloid burden in patients with cognitive impairment |
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| المؤلفون: | Kyoung Sook Won, Hyon Ah Lee, Jae-Ho Lee, Hae Won Kim, Hyuk Won Chang, Soo-Yeon Ahn, Jungsu S. Oh |
| المصدر: | Food & Nutrition Research Food & Nutrition Research, Vol 62, Iss 0, Pp 1-6 (2018) |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Vitamin, medicine.medical_specialty, Riboflavin, lcsh:TX341-641, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, mild cognitive impairment, beta-Carotene, Internal medicine, Pantothenic acid, medicine, Senile plaques, subjective cognitive impairment, Nutrition and Dietetics, business.industry, Public Health, Environmental and Occupational Health, Retinol, vitamin, Pyridoxine, 030104 developmental biology, Endocrinology, chemistry, pantothenic acid, Original Article, business, diet, lcsh:Nutrition. Foods and food supply, Alzheimer’s disease, 030217 neurology & neurosurgery, Niacin, Food Science, medicine.drug |
| الوصف: | Alzheimer's disease (AD) is a neurodegenerative disease characterized by the deposition of amyloid-β peptide (Aβ) in diffuse and neuritic plaques. Previous research has suggested that certain vitamins may prevent this process. In the present study, we evaluated the relationship between vitamin intake and cerebral Aβ burden in patients with cognitive impairment. This study included 19 patients with subjective cognitive impairment and 30 patients with mild cognitive impairment. All patients underwent brain MRI and 18F-florbetaben positron emission tomography. The Food Frequency Questionnaire was used to evaluate dietary intake of the 15 vitamins. Intake of vitamin B6 (p = 0.027), vitamin K (p = 0.042), vitamin A (p = 0.063), riboflavin (p = 0.063), β-carotene (p = 0.081), pantothenic acid (p = 0.092), and niacin (p = 0.097) was higher in the Aβ-positive group than in the Aβ-negative group. Multivariate linear regression analysis revealed that pantothenic acid intake was an independent determinant of cerebral Aβ burden (β = 0.287, p = 0.029). No significant correlations were observed between cerebral Aβ burden and the intake of other vitamins. Our findings demonstrated that pantothenic acid intake may be associated with increased cerebral Aβ burden in patients with cognitive impairment. These results may offer insight into potential strategies for AD prevention. |
| تدمد: | 1654-661X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3784523c34d3dcd7538a063277e9629e https://pubmed.ncbi.nlm.nih.gov/30574044 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3784523c34d3dcd7538a063277e9629e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1654661X |
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