Formulation and evalution of montelukast sodium - chitosan based spray dried microspheres for pulmonary drug delivery
| العنوان: | Formulation and evalution of montelukast sodium - chitosan based spray dried microspheres for pulmonary drug delivery |
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| المؤلفون: | Harsha V. Patel, Ankit Parikh, Rushi Panchal, Vishnu Patel, Pratik Joshi |
| المساهمون: | Panchal, Rushi, Patel, Harsha, Patel, Vishnu, Joshi, Pratik, Parikh, Ankit |
| المصدر: | Journal of Pharmacy & Bioallied Sciences Journal of Pharmacy and Bioallied Sciences, Vol 4, Iss 5, Pp 110-111 (2012) |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | mucosdhesion, Materials science, lcsh:Analytical chemistry, Original/Brief, lcsh:RS1-441, Bioengineering, gluteraldehyde, General Biochemistry, Genetics and Molecular Biology, Chitosan, lcsh:Pharmacy and materia medica, chemistry.chemical_compound, Polymer ratio, montelukast sodium, Mucoadhesion, medicine, General Pharmacology, Toxicology and Pharmaceutics, sodium, lcsh:QD71-142, microspheres, chemistry, Spray drying, Drug delivery, montelukast, Particle size, Glutaraldehyde, Swelling, medicine.symptom, chitosan, Nuclear chemistry, spray dryer |
| الوصف: | The objective of present work was to prepare microspheres of montelukast sodium using a natural polymer-chitosan by spray drying method by using glutaraldehyde as a cross linking agent. The microspheres were characterized for size, shape, dissolution, swelling and mucoadhesion. It was observed that, all microspheres were spherical in shape with narrow size distribution. Microspheres had mean particle size of 7-12 m, with % encapsulation efficiency of 78-86%. The % yield was 32-49% and drug load was 48-53%. With the increase in proportion of chitosan in formulation mucoadhesive strength was increase and also increased in particle size of microspheres. As the drug:polymer ratio increase drug loading was increase and % encapsulation efficiency was also increase. Refereed/Peer-reviewed |
| تدمد: | 0975-7406 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::377af5ec04b1066032bf6d8b3e80ecc3 https://pubmed.ncbi.nlm.nih.gov/23066182 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....377af5ec04b1066032bf6d8b3e80ecc3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09757406 |
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