Eating ‘Junk-Food’ Produces Rapid and Long-Lasting Increases in NAc CP-AMPA Receptors: Implications for Enhanced Cue-Induced Motivation and Food Addiction
| العنوان: | Eating ‘Junk-Food’ Produces Rapid and Long-Lasting Increases in NAc CP-AMPA Receptors: Implications for Enhanced Cue-Induced Motivation and Food Addiction |
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| المؤلفون: | Luis F. Lopez-Santiago, Max F. Oginsky, Paulette B. Goforth, Carrie R. Ferrario, Cameron W Nobile |
| المصدر: | Neuropsychopharmacology |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_specialty, Food addiction, media_common.quotation_subject, Craving, AMPA receptor, Nucleus accumbens, Nucleus Accumbens, Developmental psychology, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Cocaine, Dopamine Uptake Inhibitors, Internal medicine, medicine, Animals, Obesity, Receptors, AMPA, media_common, Pharmacology, Motivation, Addiction, digestive, oral, and skin physiology, Feeding Behavior, medicine.disease, Rats, Behavior, Addictive, Disease Models, Animal, Psychiatry and Mental health, 030104 developmental biology, Endocrinology, Gene Expression Regulation, Food, Schizophrenia, Calcium, Original Article, Psychopharmacology, Cues, medicine.symptom, Psychology, Locomotion, 030217 neurology & neurosurgery |
| الوصف: | Urges to eat are influenced by stimuli in the environment that are associated with food (food cues). Obese people are more sensitive to food cues, reporting stronger craving and consuming larger portions after food cue exposure. The nucleus accumbens (NAc) mediates cue-triggered motivational responses, and activations in the NAc triggered by food cues are stronger in people who are susceptible to obesity. This has led to the idea that alterations in NAc function similar to those underlying drug addiction may contribute to obesity, particularly in obesity-susceptible individuals. Motivational responses are mediated in part by NAc AMPA receptor (AMPAR) transmission, and recent work shows that cue-triggered motivation is enhanced in obesity-susceptible rats after ‘junk-food' diet consumption. Therefore, here we determined whether NAc AMPAR expression and function is increased by ‘junk-food' diet consumption in obesity-susceptible vs -resistant populations using both outbred and selectively bred models of susceptibility. In addition, cocaine-induced locomotor activity was used as a general ‘read out' of mesolimbic function after ‘junk-food' consumption. We found a sensitized locomotor response to cocaine in rats that gained weight on a ‘junk-food' diet, consistent with greater responsivity of mesolimbic circuits in obesity-susceptible groups. In addition, eating ‘junk-food' increased NAc calcium-permeable-AMPAR (CP-AMPAR) function only in obesity-susceptible rats. This increase occurred rapidly, persisted for weeks after ‘junk-food' consumption ceased, and preceded the development of obesity. These data are considered in light of enhanced cue-triggered motivation and striatal function in obesity-susceptible rats and the role of NAc CP-AMPARs in enhanced motivation and addiction. |
| تدمد: | 1740-634X 0893-133X |
| DOI: | 10.1038/npp.2016.111 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3729315bbad3e83cfebf327753a9ecc0 https://doi.org/10.1038/npp.2016.111 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3729315bbad3e83cfebf327753a9ecc0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1740634X 0893133X |
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| DOI: | 10.1038/npp.2016.111 |