Mycoplasmas regulate HIV-LTR-dependent gene expression
| العنوان: | Mycoplasmas regulate HIV-LTR-dependent gene expression |
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| المؤلفون: | Alik Honigman, Shoshana Israel, Itzhak Kahane, Ran Nir-Paz |
| المصدر: | FEMS Microbiology Letters. 128:63-68 |
| بيانات النشر: | Oxford University Press (OUP), 1995. |
| سنة النشر: | 1995 |
| مصطلحات موضوعية: | CD4-Positive T-Lymphocytes, Gene Expression Regulation, Viral, HIV Infections, Biology, Microbiology, Jurkat cells, Cell Line, Transactivation, Mycoplasma, Genes, Reporter, Gene expression, Mycoplasma pirum, Genetics, Humans, Mycoplasma Infections, Molecular Biology, Gene, HIV Long Terminal Repeat, Mycoplasma fermentans, Reporter gene, virus diseases, Fibroblasts, biology.organism_classification, Virology |
| الوصف: | Mycoplasmas have been incriminated in setting the stage for HIV infection and full-blown AIDS. We tested the possible involvement of mycoplasmas in activation of HIV. Two cell lines, 293 fibroblasts and Jurkat CD4+ T-cells, transfected with plasmids harboring a transcription fusion construct between HIV-long terminal repeat (HIV-LTR) and either luc or cat genes, were infected with several mycoplasmas (M. fermentans; M. penetrans, M. pirum and Ureaplasma urealyticum) and the reporter gene expression was monitored. The data presented here suggest that mycoplasmas, and specifically their membranes, play a role in the activation of HIV-LTR mediated transcription. |
| تدمد: | 1574-6968 0378-1097 |
| DOI: | 10.1111/j.1574-6968.1995.tb07501.x |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3711a191a35838ef9a6393386bb01088 https://doi.org/10.1111/j.1574-6968.1995.tb07501.x |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3711a191a35838ef9a6393386bb01088 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15746968 03781097 |
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| DOI: | 10.1111/j.1574-6968.1995.tb07501.x |