Palladium-Catalyzed Alkene Carboamination Reactions of Electron-Poor Nitrogen Nucleophiles

التفاصيل البيبلوغرافية
العنوان: Palladium-Catalyzed Alkene Carboamination Reactions of Electron-Poor Nitrogen Nucleophiles
المؤلفون: John P. Wolfe, Luke J. Peterson
المصدر: Advanced Synthesis & Catalysis. 357:2339-2344
بيانات النشر: Wiley, 2015.
سنة النشر: 2015
مصطلحات موضوعية: Reaction conditions, chemistry.chemical_classification, Alkene, Aryl, chemistry.chemical_element, General Chemistry, Nitrogen, Article, Catalysis, chemistry.chemical_compound, chemistry, Nucleophile, Yield (chemistry), Organic chemistry, Palladium
الوصف: Modified reaction conditions that facilitate Pd-catalyzed alkene carboamination reactions of electron-deficient nitrogen nucleophiles are reported. Pent-4-enylamine derivatives bearing N-tosyl or N-trifluoroacetyl groups are coupled with aryl triflates to afford substituted pyrrolidines in good yield. These reactions proceed via a mechanism involving anti-aminopalladation of the alkene, which differs from previously reported analogous reactions of N-aryl and N-boc pentenylamines. The application of these conditions to a formal synthesis of (±)-aphanorphine is also described.
تدمد: 1615-4150
DOI: 10.1002/adsc.201500334
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36f652e742f4add093df32dd50c1ee92
https://doi.org/10.1002/adsc.201500334
Rights: OPEN
رقم الانضمام: edsair.doi.dedup.....36f652e742f4add093df32dd50c1ee92
قاعدة البيانات: OpenAIRE
الوصف
تدمد:16154150
DOI:10.1002/adsc.201500334