Search for New Candidate Genes Involved in the Comorbidity of Asthma and Hypertension Based on Automatic Analysis of Scientific Literature
| العنوان: | Search for New Candidate Genes Involved in the Comorbidity of Asthma and Hypertension Based on Automatic Analysis of Scientific Literature |
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| المؤلفون: | Ralf Hofestaedt, Maxim B. Freidin, Victor E. Dosenko, P. S. Demenkov, Olga V. Saik, Evgeniy L. Choynzonov, Timofey V. Ivanisenko, Elena Yu. Bragina, Vladimir A. Ivanisenko, Olga Zolotareva |
| المصدر: | Saik, O V, Demenkov, P S, Ivanisenko, T V, Bragina, E Y, Freidin, M B, Dosenko, V E, Zolotareva, O I, Choynzonov, E L, Hofestaedt, R & Ivanisenko, V A 2018, ' Search for New Candidate Genes Involved in the Comorbidity of Asthma and Hypertension Based on Automatic Analysis of Scientific Literature ', Journal of integrative bioinformatics, vol. 15, no. 4, 20180054 . https://doi.org/10.1515/jib-2018-0054 Journal of Integrative Bioinformatics, Vol 15, Iss 4, Pp 820-8 (2018) Journal of Integrative Bioinformatics |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Candidate gene, gene prioritization, hypertension, ANDSystem, Gene regulatory network, Comorbidity, Computational biology, Biology, 03 medical and health sciences, Germany, medicine, comorbid disease, Data Mining, Humans, dynamics of interest of genes in publications, Gene Regulatory Networks, KEGG, Gene, Computational Biology, General Medicine, Phenotypic trait, asthma, medicine.disease, 030104 developmental biology, IL1A, andsystem, associative gene network, Centrality, Biomarkers, Software, TP248.13-248.65, Research Article, Biotechnology |
| الوصف: | Comorbid states of diseases significantly complicate diagnosis and treatment. Molecular mechanisms of comorbid states of asthma and hypertension are still poorly understood. Prioritization is a way for identifying genes involved in complex phenotypic traits. Existing methods of prioritization consider genetic, expression and evolutionary data, molecular-genetic networks and other. In the case of molecular-genetic networks, as a rule, protein-protein interactions and KEGG networks are used. ANDSystem allows reconstructing associative gene networks, which include more than 20 types of interactions, including protein-protein interactions, expression regulation, transport, catalysis, etc. In this work, a set of genes has been prioritized to find genes potentially involved in asthma and hypertension comorbidity. The prioritization was carried out using well-known methods (ToppGene and Endeavor) and a cross-talk centrality criterion, calculated by analysis of associative gene networks from ANDSystem. The identified genes, including IL1A, CD40LG, STAT3, IL15, FAS, APP, TLR2, C3, IL13 and CXCL10, may be involved in the molecular mechanisms of comorbid asthma/hypertension. An analysis of the dynamics of the frequency of mentioning the most priority genes in scientific publications revealed that the top 100 priority genes are significantly enriched with genes with increased positive dynamics, which may be a positive sign for further studies of these genes. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1515/jib-2018-0054 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369357e7051f367bcf4d1bdb114ae864 https://kclpure.kcl.ac.uk/ws/files/109655339/Search_for_New_Candidate_Genes_SAIK_Published_25_December_2018_GOLD_VoR_CC_BY_NC_ND_.pdf |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....369357e7051f367bcf4d1bdb114ae864 |
| قاعدة البيانات: | OpenAIRE |
| DOI: | 10.1515/jib-2018-0054 |
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