Withdrawal from Extended, Intermittent Access to A Highly Palatable Diet Impairs Hippocampal Memory Function and Neurogenesis: Effects of Memantine
| العنوان: | Withdrawal from Extended, Intermittent Access to A Highly Palatable Diet Impairs Hippocampal Memory Function and Neurogenesis: Effects of Memantine |
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| المؤلفون: | Pietro Cottone, Clara Velázquez-Sánchez, Ali Al Abdullatif, Antonio Ferragud, Valentina Sabino |
| المساهمون: | Ferragud, Antonio [0000-0002-6739-007X], Apollo - University of Cambridge Repository |
| المصدر: | Nutrients, Vol 12, Iss 1520, p 1520 (2020) Nutrients Volume 12 Issue 5 |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, medicine.medical_specialty, Hippocampus, lcsh:TX341-641, Hippocampal formation, Receptors, N-Methyl-D-Aspartate, Article, Feeding and Eating Disorders, 03 medical and health sciences, Eating, 0302 clinical medicine, Memantine, Memory, Internal medicine, Hypophagia, medicine, Animals, Rats, Wistar, Memory Disorders, Nutrition and Dietetics, Behavior, Animal, business.industry, Dentate gyrus, compulsive eating, Neurogenesis, Body Weight, digestive, oral, and skin physiology, Antagonist, Diet, Rats, Disease Models, Animal, neurogenesis, 030104 developmental biology, Endocrinology, NMDA, NMDA receptor, Food Addiction, business, lcsh:Nutrition. Foods and food supply, 030217 neurology & neurosurgery, Food Science, medicine.drug |
| الوصف: | Background: Compulsive eating can be promoted by intermittent access to palatable food and is often accompanied by cognitive deficits and reduction in hippocampal plasticity. Here, we investigated the effects of intermittent access to palatable food on hippocampal function and neurogenesis. Methods: Male Wistar rats were either fed chow for 7 days/week (Chow/Chow group), or fed chow intermittently for 5 days/week followed by a palatable diet for 2 days/week (Chow/Palatable group). Hippocampal function and neurogenesis were assessed either during withdrawal or following renewed access to palatable food. Furthermore, the ability of the uncompetitive N-methyl-d-aspartate receptor (NMDAR) antagonist memantine to prevent the diet-induced memory deficits and block the maladaptive feeding was tested. Results: Palatable food withdrawn Chow/Palatable rats showed both a weakened ability for contextual spatial processing and a bias in their preference for a &ldquo novel cue&rdquo over a &ldquo novel place,&rdquo compared to controls. They also showed reduced expression of immature neurons in the dentate gyrus of the hippocampus as well as a withdrawal-dependent decrease of proliferating cells. Memantine treatment was able both to reverse the memory deficits and to reduce the excessive intake of palatable diet and the withdrawal-induced hypophagia in food cycling rats. Conclusions: In summary, our results provide evidence that withdrawal from highly palatable food produces NMDAR-dependent deficits in hippocampal function and a reduction in hippocampal neurogenesis. |
| وصف الملف: | application/pdf; text/xml; application/zip |
| اللغة: | English |
| تدمد: | 2072-6643 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3683162c6dd4d79c28b1b530b58d5049 https://www.mdpi.com/2072-6643/12/5/1520 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3683162c6dd4d79c28b1b530b58d5049 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726643 |
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