Association between alcohol use and inflammatory biomarkers over time among younger adults with HIV—The Russia ARCH Observational Study
| العنوان: | Association between alcohol use and inflammatory biomarkers over time among younger adults with HIV—The Russia ARCH Observational Study |
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| المؤلفون: | Gregory Patts, Russell P. Tracy, Dmitry Lioznov, Laura F. White, Jeffrey H. Samet, Natalia Gnatienko, Natalie E. Chichetto, Carly Bridden, Evgeny Krupitsky, Yicheng Ma, Elena Blokhina, Kendall J. Bryant, Debbie M. Cheng, Matthew S. Freiberg, Kaku So-Armah, Margaret F. Doyle |
| المصدر: | PLoS ONE, Vol 14, Iss 8, p e0219710 (2019) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | RNA viruses, Male, Gastroenterology and hepatology, Lipopolysaccharide Receptors, Alcohol abuse, HIV Infections, Alcohol, 030312 virology, Pathology and Laboratory Medicine, Biochemistry, Hepatitis, Russia, Cohort Studies, chemistry.chemical_compound, 0302 clinical medicine, Immunodeficiency Viruses, Medicine and Health Sciences, Public and Occupational Health, Longitudinal Studies, 030212 general & internal medicine, Immune Response, 0303 health sciences, Alcohol Consumption, Multidisciplinary, Confounding, HIV diagnosis and management, Hepatitis C, Recreational drug use, Vaccination and Immunization, 3. Good health, Infectious hepatitis, Medical Microbiology, Behavioral Pharmacology, Viral Pathogens, Viruses, Infectious diseases, Medicine, Biomarker (medicine), Female, Pathogens, Inflammation Mediators, Research Article, Adult, medicine.medical_specialty, Alcohol Drinking, Science, Immunology, Antiretroviral Therapy, Viral diseases, Microbiology, Fibrin Fibrinogen Degradation Products, 03 medical and health sciences, Signs and Symptoms, Antiviral Therapy, Acquired immunodeficiency syndrome (AIDS), Recreational Drug Use, Internal medicine, Retroviruses, medicine, Humans, Microbial Pathogens, Liver diseases, Nutrition, Inflammation, Pharmacology, Interleukin-6, business.industry, Lentivirus, Organisms, Biology and Life Sciences, HIV, medicine.disease, Diagnostic medicine, Diet, chemistry, Linear Models, Phosphatidylethanol, Preventive Medicine, business, Biomarkers |
| الوصف: | BackgroundBiomarkers of monocyte activation (soluble CD14 [sCD14]), inflammation (interleukin-6 [IL-6]), and altered coagulation (D-dimer) are associated with increased mortality risk in people with HIV. The objective of the Russia Alcohol Research Collaboration on HIV/AIDS (ARCH) study was to evaluate the association between heavy alcohol use and inflammatory biomarkers over time.MethodsThe study sought antiretroviral therapy naive participants with HIV (n = 350) and assessed them at baseline, 12 and 24 months. Linear mixed effects models were used to determine whether heavy drinking (self-report augmented by phosphatidylethanol [PEth], an alcohol biomarker) was longitudinally associated with IL-6, sCD14 and D-dimer adjusting for potential confounders (e.g., demographics, HIV factors, comorbid conditions).ResultsParticipants' baseline characteristics were as follows: 71% male; mean age of 34 years; 87% self-reported hepatitis C; and 86% current smokers. Mean log10 (HIV RNA) was 4.3 copies/mL. Heavy alcohol use, based on National Institute of Alcohol Abuse and Alcoholism risky drinking criteria and PEth (versus non-heavy alcohol use) was associated with higher sCD14 (adjusted mean difference 125 ng/mL [95% CI: 42, 209]), IL-6 (ratio of means 1.35 [95% CI: 1.17, 1.55] pg/mL), and D-dimer (ratio of means 1.20 [95% CI: 1.06, 1.37] ug/mL) across the two-year follow-up.ConclusionAmong HIV+ adults, current heavy alcohol use is associated with higher sCD14, IL-6 and D-dimer over time. Since these biomarkers are associated with mortality, interventions to mitigate effects of heavy drinking on these immune processes merit consideration. |
| تدمد: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0219710 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35a76313ced8adb4fa02e9ad09bdbe9e https://doi.org/10.1371/journal.pone.0219710 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....35a76313ced8adb4fa02e9ad09bdbe9e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0219710 |