SARS-CoV-2 involvement in central nervous system tissue damage
| العنوان: | SARS-CoV-2 involvement in central nervous system tissue damage |
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| المؤلفون: | Zaynab Shakkour, Firas Kobeissy, Hasan Kaafarani, Perla Chamoun, Esber S. Saba, Nadine Al-Haj, Karl John Habashy, Maya Bizri, Mohammad Amine Reslan, Sarah H. Farran, Bassam Badran, Muhammad Ali Haidar, Mirna Sabra, Abdullah Shaito, Shima Shahjouei |
| المصدر: | Neural Regeneration Research, Vol 17, Iss 6, Pp 1228-1239 (2022) Neural Regeneration Research |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | autoantibodies, encephalitis, viruses, Central nervous system, renin-angiotensin system, Disease, Review, medicine.disease_cause, Virus, coagulopathy, neuroinflammation, Cerebrospinal fluid, Immune system, Developmental Neuroscience, medicine, CNS infection, cns infection, covid-19, viral encephalopathy, RC346-429, Neuroinflammation, Coronavirus, business.industry, COVID-19, medicine.anatomical_structure, Immunology, Neurology. Diseases of the nervous system, Headaches, medicine.symptom, business |
| الوصف: | As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread globally, it became evident that the SARS-CoV-2 virus infects multiple organs including the brain. Several clinical studies revealed that patients with COVID-19 infection experience an array of neurological signs ranging in severity from headaches to life-threatening strokes. Although the exact mechanism by which the SARS-CoV-2 virus directly impacts the brain is not fully understood, several theories have been suggested including direct and indirect pathways induced by the virus. One possible theory is the invasion of SARS-CoV-2 to the brain occurs either through the bloodstream or via the nerve endings which is considered to be the direct route. Such findings are based on studies reporting the presence of viral material in the cerebrospinal fluid and brain cells. Nevertheless, the indirect mechanisms, including blood-clotting abnormalities and prolonged activation of the immune system, can result in further tissue and organ damages seen during the course of the disease. This overview attempts to give a thorough insight into SARS-CoV-2 coronavirus neurological infection and highlights the possible mechanisms leading to the neurological manifestations observed in infected patients. |
| اللغة: | English |
| تدمد: | 1673-5374 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35a1cf65f7a1c70422f48f14cd1babf4 http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=6;spage=1228;epage=1239;aulast=Haidar |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....35a1cf65f7a1c70422f48f14cd1babf4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16735374 |
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